Häuptli W, Stähelin H B, Gyr K, Bianchi L
Schweiz Med Wochenschr Suppl. 1979(9):1-18.
Benign symmetric lipomatosis (BSL) leads to characteristic multiple lipomas of the neck and submandibular region. BSL is easily diagnosed by its typical feature, "Madelung's neck". However, the early stages are often missed or lead to futile diagnostic endeavours. A report is presented on 7 men with BSL aged 36--65 years who were investigated with regard to alcohol consumption, clinical findings and liver histology. This is the first time that liver histology has been systematically worked up in patients with BSL. All admitted long standing ethanol intake (x = 111 ml/day) prior to the development of BSL. The growth of the lipomas was irregular and occurred over a period of months. There was no correlation with overweight or hyperlipidemia. However, liver biopsy revealed features consistent with alcoholic liver disease in all subjects. It is suggested that BSL is a symptom of alcoholic liver disease mainly affecting middle-aged men.
良性对称性脂肪瘤病（BSL）会导致颈部和下颌下区域出现典型的多发性脂肪瘤。BSL通过其典型特征“马德隆颈”很容易诊断。然而，早期阶段常常被漏诊或导致徒劳的诊断努力。本文报告了7例年龄在36至65岁的BSL男性患者，对他们的饮酒情况、临床症状和肝脏组织学进行了调查。这是首次对BSL患者的肝脏组织学进行系统研究。所有患者在BSL发病前均长期摄入乙醇（平均每天111毫升）。脂肪瘤生长不规则，持续数月。与超重或高脂血症无关。然而，肝脏活检显示所有受试者均有与酒精性肝病相符的特征。提示BSL是主要影响中年男性的酒精性肝病的一种症状。
