Center for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, China.
Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, China.
Front Cell Infect Microbiol. 2024 Jan 3;13:1273254. doi: 10.3389/fcimb.2023.1273254. eCollection 2023.
The in-depth studies reveal the interaction between the host and commensal microbiomes. Symbiotic bacteria influence in tumor initiation, progression, and response to treatment. Recently, intratumor bacteria have been a burgeoning research field. The tumor microenvironment is under vascular hyperplasia, aerobic glycolysis, hypoxia, and immunosuppression. It might be attractive for bacterial growth and proliferation. As a component of the tumor microenvironment, intratumor bacteria influence tumor growth and metastasis, as well as the efficacy of anti-tumor therapies. Therefore, understanding the intricate interplay of intratumoral bacteria and the host might contribute to better approaches to treat tumors. In this review, we summarize current evidence about roles of intratumor bacteria in tumor initiation and anti-tumor therapy, and what is remained to be solved in this field.
深入的研究揭示了宿主与共生微生物组之间的相互作用。共生细菌影响肿瘤的发生、发展和对治疗的反应。最近，肿瘤内细菌已成为一个新兴的研究领域。肿瘤微环境存在血管增生、有氧糖酵解、缺氧和免疫抑制。这可能有利于细菌的生长和增殖。作为肿瘤微环境的一部分，肿瘤内细菌影响肿瘤的生长和转移，以及抗肿瘤治疗的疗效。因此，了解肿瘤内细菌与宿主之间的复杂相互作用可能有助于更好地治疗肿瘤。在这篇综述中，我们总结了目前关于肿瘤内细菌在肿瘤发生和抗肿瘤治疗中的作用的证据，以及该领域仍需解决的问题。
