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一种用于多方面肿瘤微环境干预的肿瘤内细菌靶向DNA纳米载体。

An intratumor bacteria-targeted DNA nanocarrier for multifaceted tumor microenvironment intervention.

作者信息

Wang Yibiao, Fu Xiaomei, Zhu Yang, Lin Mingjing, Cai Renduan, Zhu Yang, Wu Tiantian

机构信息

Department of Neurosurgery/Department of Pediatrics/Department of Neonatal, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570311, China.

Fujian Provincial Institutes of Brain Disorders and Brain Sciences/Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.

出版信息

Mater Today Bio. 2024 Jul 3;27:101144. doi: 10.1016/j.mtbio.2024.101144. eCollection 2024 Aug.

DOI:10.1016/j.mtbio.2024.101144
PMID:39070095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11279327/
Abstract

Intratumor bacteria, which are involved with complex tumor development mechanisms, can compromise the therapeutic efficiencies of cancer chemotherapeutics. Therefore, the development of anti-tumor agents targeting intratumor bacteria is crucial in overcoming the drug inactivation induced by bacteria colonization. In this study, a double-bundle DNA tetrahedron-based nanocarrier is developed for intratumor bacteria-targeted berberine (Ber) delivery. The combination of aptamer modification and high drug loading efficacy endow the DNA nanocarrier TA@B with enhanced delivery performance in anti-tumor therapy without obvious systemic toxicity. The loaded natural isoquinoline alkaloid Ber exhibits enhanced antimicrobial, anticancer, and immune microenvironment regulation effects, ultimately leading to efficient inhibition of tumor proliferation. This intratumor bacteria-targeted DNA nanoplatform provides a promising strategy in intervening the bacteria-related microenvironment and facilitating tumor therapy.

摘要

肿瘤内细菌参与复杂的肿瘤发展机制，会削弱癌症化疗药物的治疗效果。因此，开发针对肿瘤内细菌的抗肿瘤药物对于克服细菌定植引起的药物失活至关重要。在本研究中，开发了一种基于双束DNA四面体的纳米载体，用于肿瘤内细菌靶向递送黄连素（Ber）。适配体修饰与高载药效率的结合赋予DNA纳米载体TA@B在抗肿瘤治疗中增强的递送性能，且无明显的全身毒性。负载的天然异喹啉生物碱Ber表现出增强的抗菌、抗癌和免疫微环境调节作用，最终有效抑制肿瘤增殖。这种肿瘤内细菌靶向DNA纳米平台为干预细菌相关微环境和促进肿瘤治疗提供了一种有前景的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/fc3479ec5283/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/da06f3975538/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/a71949d1d713/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/a1f4416680b3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/fd606cfa4fab/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/b624df4bf57a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/d30f7fc5e295/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/994cfbaebfdb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/fc3479ec5283/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/da06f3975538/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/a71949d1d713/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/a1f4416680b3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/fd606cfa4fab/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/b624df4bf57a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/d30f7fc5e295/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/994cfbaebfdb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ab/11279327/fc3479ec5283/gr6.jpg

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