Larsson L I, Goltermann N, de Magistris L, Rehfeld J F, Schwartz T W
Science. 1979 Sep 28;205(4413):1393-5. doi: 10.1126/science.382360.
Somatostatin is produced by gastrointestinal endocrine cells that have long, nonluminal, cytoplasmic processes. Such processes terminate on other cell types, including gastrin-producing and hydrochloric acid-producing cells, whose functions are profoundly affected by somatostatin. The findings suggest that somatostatin cells control the functions of other cells through local release of the peptide by way of cytoplasmic processes. Also, certain other types of gastrointestinal endocrine cells have similar cytoplasmic prolongations, which may have analogous local (paracrine) regulatory functions.
生长抑素由胃肠道内分泌细胞产生，这些细胞具有长的、非管腔的细胞质突起。这些突起终止于其他细胞类型，包括产生胃泌素的细胞和产生盐酸的细胞，其功能受到生长抑素的深刻影响。这些发现表明，生长抑素细胞通过细胞质突起局部释放该肽来控制其他细胞的功能。此外，某些其他类型的胃肠道内分泌细胞也有类似的细胞质延长部分，可能具有类似的局部（旁分泌）调节功能。
