Gustavsson S, Lundquist G
Acta Endocrinol (Copenh). 1978 Jun;88(2):339-46. doi: 10.1530/acta.0.0880339.
In anaesthetized pigs gastrin release was stimulated by irrigation of the antrum with bicarbonate and by instillation of a meat extract. The concentration of gastrin and somatostatin was measured by radioimmunoassay both in the antral and peripheral venous blood. The increase in gastrin was coupled to a significant decrease in somatostatin immunoreactivity as measured in the antral venous blood both during instillation of alkali and meat extract. In peripheral blood, the differences were much less evident and not statistically significant. It is speculated that the decrease in release of antral somatostatin during alkalinization and instillation of meat extract is the primary event which is followed by a diminished inhibition of gastrin liberation. Thus, the present data support the hypothesis that antral somatostatin participates in the local regulation of gastrin release.
在麻醉的猪身上，用碳酸氢盐冲洗胃窦和滴注肉提取物可刺激胃泌素释放。通过放射免疫分析法测定胃窦和外周静脉血中胃泌素和生长抑素的浓度。在滴注碱和肉提取物期间，胃窦静脉血中测得的胃泌素增加与生长抑素免疫反应性的显著降低相关。在外周血中，差异不太明显且无统计学意义。据推测，碱化和肉提取物滴注期间胃窦生长抑素释放的减少是主要事件，随后胃泌素释放的抑制减弱。因此，目前的数据支持胃窦生长抑素参与胃泌素释放局部调节的假说。
