Laboratory of Neurobiology, CIMES, University of Malaga, Malaga, Spain.
Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain.
Eur J Neurosci. 2024 Apr;59(7):1743-1752. doi: 10.1111/ejn.16243. Epub 2024 Jan 18.
Perirhinal cortex is a brain area that has been considered crucial for the object recognition memory (ORM). However, with the use of an ORM enhancer named RGS14 as gain-in-function tool, we show here that frontal association cortex and not the Perirhinal cortex is essential for the ORM of objects with complex features that consisted of detailed drawing on the object surface (complex ORM). An expression of RGS14, in rat brain frontal association cortex, induced the formation of long-term complex ORM, whereas the expression of the same memory enhancer in Perirhinal cortex failed to produce this effect. Instead, RGS14 expression in Perirhinal cortex caused the formation of ORM of objects with simple features that consisted of the shape of object (simple ORM). Further, a selective elimination of frontal association cortex neurons by treatment with an immunotoxin Ox7-SAP completely abrogated the formation of complex ORM. Thus, our results suggest that frontal association cortex plays a key role in processing of a high-order recognition memory information in brain.
扣带皮层是大脑中被认为对物体识别记忆（ORM）至关重要的区域。然而，使用一种名为 RGS14 的 ORM 增强剂作为功能获得工具，我们在这里表明，额联合皮层而不是 Perirhinal 皮层对于具有复杂特征的物体的 ORM 是必不可少的，这些特征包括物体表面的详细绘图（复杂 ORM）。RGS14 在大鼠大脑额联合皮层中的表达诱导了长期复杂 ORM 的形成，而相同的记忆增强剂在 Perirhinal 皮层中的表达未能产生这种效果。相反，RGS14 在 Perirhinal 皮层中的表达导致了由物体形状组成的具有简单特征的物体的 ORM 的形成（简单 ORM）。此外，用免疫毒素 Ox7-SAP 选择性消除额联合皮层神经元完全消除了复杂 ORM 的形成。因此，我们的结果表明，额联合皮层在大脑中处理高级识别记忆信息方面发挥着关键作用。
