Department of Psychology, Trinity University, San Antonio, Texas, USA.
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Am J Primatol. 2024 Apr;86(4):e23597. doi: 10.1002/ajp.23597. Epub 2024 Jan 18.
Human aging is associated with senescence of the hypothalamic-pituitary-adrenal (HPA) axis, leading to progressive dysregulation characterized by increased cortisol exposure. This key hormone is implicated in the pathogenesis of many age-related diseases. Common marmosets (Callithrix jacchus) display a wide spectrum of naturally occurring age-related pathologies that compare similarly to humans and are increasingly used as translational models of aging and age-related disease. Whether the marmoset HPA axis also shows senescence with increasing age is unknown. We analyzed hair cortisol concentration (HCC) across the lifespan of 50 captive common marmosets, ranging in age from approximately 2 months-14.5 years, via a cross-sectional design. Samples were processed and analyzed for cortisol using enzyme immunoassay. HCC ranged from 1416 to 15,343 pg/mg and was negatively correlated with age. We found significant main effects of age group (infant, adolescent, adult, aged, very aged) and sex on HCC, and no interaction effects. Infants had significantly higher levels of HCC compared with all other age groups. Females had higher HCC than males. There was no interaction between age and sex. These results suggest marmosets do not show dysregulation of the HPA axis with increasing age, as measured via HCC.
人类衰老与下丘脑-垂体-肾上腺（HPA）轴的衰老有关，导致以皮质醇暴露增加为特征的进行性失调。这种关键激素与许多与年龄相关的疾病的发病机制有关。普通狨猴（Callithrix jacchus）表现出广泛的自然发生的与年龄相关的病理，与人类相似，并越来越多地被用作衰老和与年龄相关的疾病的转化模型。狨猴的 HPA 轴是否也会随着年龄的增长而出现衰老还不得而知。我们通过横断面设计分析了 50 只圈养普通狨猴在整个生命周期中的头发皮质醇浓度（HCC），年龄从大约 2 个月到 14.5 岁不等。使用酶免疫分析法对样品进行处理和皮质醇分析。HCC 的范围为 1416 到 15,343 pg/mg，与年龄呈负相关。我们发现 HCC 与年龄组（婴儿、青少年、成年、老年、非常老年）和性别存在显著的主效应，而没有交互效应。与其他所有年龄组相比，婴儿的 HCC 水平显著更高。女性的 HCC 水平高于男性。年龄和性别之间没有相互作用。这些结果表明，狨猴的 HPA 轴没有随着年龄的增长而出现失调，这可以通过 HCC 来衡量。
