Chen Juan, Hu Chunyan, Chen Guiying, Zhang Yi
Department of Gynaecology, Panzhihua Maternal and Child Health Hospital (Panzhihua Women & Children Hospital), Panzhihua City, Sichuan Province, China.
Department of Gynaecology, Hainan General Hospital, Haikou City, Hainan Province, China.
Nucleosides Nucleotides Nucleic Acids. 2024;43(10):1114-1128. doi: 10.1080/15257770.2024.2302525. Epub 2024 Jan 19.
The importance of Vitamin D in ovarian cancer (OC) has been well documented, and lower levels have been associated with susceptibility to OC. Vitamin D exerts its effect through the vitamin D receptor (VDR). Common genetic variants in the VDR gene (, , and ) have been linked with the susceptibility to the development of OC; however, the reports remain contradictory. To draw a valid conclusion, we performed a meta-analysis of the earlier published reports in the present study. The literature search was performed in PubMed, Google Scholar, and Scopus databases. All relevant articles were screened, and eligible reports were identified based on prefixed inclusion and exclusion criteria. Data such as author's details, year of publication, ethnicity, genotype and allele prevalence in cases and controls were extracted from the eligible reports. The meta-analysis was performed using Comprehensive Meta-analysis Software (CMA) V3. Eight articles, including data from fourteen independent cohorts, comprised 4276 cases and 6739 healthy controls considered for the analysis. VDR and variants revealed a significant association with an increased risk of OC. Other VDR polymorphisms ( and ) failed to demonstrate such an association with OC. Interestingly, the sensitivity analysis revealed minimal deviation from the parent meta-analysis, supporting the robustness of the present analysis. The trial sequential analysis revealed the inclusion of a sufficient number of studies for polymorphism. It highlighted the requirement for additional case-control studies in VDR (, and ) to draw a definitive conclusion. and polymorphisms are associated with susceptibility to OC.
维生素D在卵巢癌（OC）中的重要性已有充分记载，其水平较低与患OC的易感性相关。维生素D通过维生素D受体（VDR）发挥作用。VDR基因中的常见基因变异（、、和）与OC发生的易感性有关；然而，相关报道仍相互矛盾。为得出有效结论，我们在本研究中对早期发表的报告进行了荟萃分析。在PubMed、谷歌学术和Scopus数据库中进行文献检索。筛选所有相关文章，并根据预先设定的纳入和排除标准确定符合条件的报告。从符合条件的报告中提取作者详细信息、发表年份、种族、病例和对照中的基因型及等位基因频率等数据。使用综合荟萃分析软件（CMA）V3进行荟萃分析。八项文章，包括来自14个独立队列的数据，共纳入4276例病例和6739例健康对照进行分析。VDR和变异与OC风险增加显著相关。其他VDR多态性（和）未显示出与OC有此类关联。有趣的是，敏感性分析显示与原始荟萃分析的偏差极小，支持了本分析的稳健性。试验序贯分析表明纳入了足够数量的关于多态性的研究。它强调需要在VDR（、和）方面进行更多病例对照研究以得出明确结论。和多态性与OC易感性相关。
