State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.
School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Food Funct. 2024 Feb 5;15(3):1598-1611. doi: 10.1039/d3fo02739b.
Psychobiotics that modulate the gut-brain axis have emerged as promising interventions for clinical mental disorders. CCFM1025 has demonstrated antidepressant effects in both mice and patients with major depression. Nevertheless, the precise mechanism of action of CCFM1025 in emotional regulation remains ambiguous. This study aimed to explore the colonization capacity of CCFM1025 and its dose-dependent effect on emotional regulation in mice exposed to chronic unpredictable mild stress (CUMS). Additionally, we examined its regulatory effects on intestinal and serum metabolites in mice. The results revealed that CCFM1025 did not exhibit a heightened gut retention capability compared to the conspecific control strain. Nevertheless, CCFM1025 exhibited dose-dependent mitigation of anxiety-like behavior and memory impairment induced by CUMS, while also restoring gut microbiota homeostasis. Notably, CCFM1025 demonstrated a robust ability to exert potent gut metabolite regulation, resulting in significant elevation of bile acid and tryptophan metabolites in the gut contents and serum of mice. These findings indicate that the impact of CCFM1025 on emotional regulation may be attributed to its regulation of gut metabolites rather than its gut retention capability. The potential of to modulate bile acid metabolism may serve as a valuable avenue for regulating the gut microbiota and successfully exert emotion regulation.
肠道-脑轴调节剂已成为治疗临床精神疾病的有前途的干预措施。CCFM1025 在小鼠和重度抑郁症患者中均显示出抗抑郁作用。然而，CCFM1025 在情绪调节中的确切作用机制仍不清楚。本研究旨在探讨 CCFM1025 的定植能力及其在慢性不可预测轻度应激（CUMS）暴露小鼠中的情绪调节的剂量依赖性效应。此外，我们还研究了其对小鼠肠道和血清代谢物的调节作用。结果表明，与同种对照菌株相比，CCFM1025 并没有表现出更高的肠道保留能力。然而，CCFM1025 表现出剂量依赖性减轻 CUMS 引起的焦虑样行为和记忆障碍，同时恢复肠道微生物组平衡。值得注意的是，CCFM1025 表现出强大的调节肠道代谢物的能力，导致小鼠肠道内容物和血清中胆汁酸和色氨酸代谢物显著升高。这些发现表明，CCFM1025 对情绪调节的影响可能归因于其对肠道代谢物的调节，而不是其肠道保留能力。调节胆汁酸代谢的潜力可能为调节肠道微生物组和成功发挥情绪调节作用提供了有价值的途径。
