Yang Tzong-Hann, Cheng Yen-Fu, Chen Chin-Shyan, Lin Herng-Ching
Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.
Department of Speech, Language and Audiology, National Taipei University of Nursing and Health, Taipei, Taiwan.
Head Neck. 2023 Nov;45(11):2874-2881. doi: 10.1002/hed.27518. Epub 2023 Sep 22.
This study aimed to investigate prevalences of head and neck cancers in patients with and those without Sjögren's syndrome using a population-based dataset.
We retrieved sampled patients from Taiwan's Longitudinal Health Insurance Database. This study included 38 930 patients with Sjögren's syndrome and 155 720 propensity-score matched comparison patients without Sjögren's syndrome.
Chi-squared tests revealed that there was a statistically significant difference in the prevalences of head and neck cancers between patients with Sjögren's syndrome and comparison patients (1.77% vs. 1.22%, p < 0.001). The odds ratio for head and neck cancers for patients with Sjögren's syndrome relative to the comparison group was 1.452 (95% CI = 1.325-1.592).
Our study demonstrated that patients with Sjögren's syndrome face increased odds of head and neck cancers, encompassing several sites including the oral cavity, oropharynx, nasopharynx, and thyroid.
本研究旨在利用基于人群的数据集，调查干燥综合征患者和非干燥综合征患者头颈癌的患病率。
我们从台湾纵向健康保险数据库中检索抽样患者。本研究纳入了38930例干燥综合征患者和155720例倾向评分匹配的非干燥综合征对照患者。
卡方检验显示，干燥综合征患者和对照患者之间头颈癌患病率存在统计学显著差异（1.77%对1.22%，p<0.001）。干燥综合征患者患头颈癌的优势比相对于对照组为1.452（95%CI=1.325-1.592）。
我们的研究表明，干燥综合征患者患头颈癌的几率增加，包括口腔、口咽、鼻咽和甲状腺等多个部位。
