干燥综合征患者头颈部癌症患病率增加。
Increased prevalences of head and neck cancers in patients with Sjögren's syndrome.
作者信息
Yang Tzong-Hann, Cheng Yen-Fu, Chen Chin-Shyan, Lin Herng-Ching
机构信息
Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.
Department of Speech, Language and Audiology, National Taipei University of Nursing and Health, Taipei, Taiwan.
出版信息
Head Neck. 2023 Nov;45(11):2874-2881. doi: 10.1002/hed.27518. Epub 2023 Sep 22.
OBJECTIVE
This study aimed to investigate prevalences of head and neck cancers in patients with and those without Sjögren's syndrome using a population-based dataset.
METHODS
We retrieved sampled patients from Taiwan's Longitudinal Health Insurance Database. This study included 38 930 patients with Sjögren's syndrome and 155 720 propensity-score matched comparison patients without Sjögren's syndrome.
RESULTS
Chi-squared tests revealed that there was a statistically significant difference in the prevalences of head and neck cancers between patients with Sjögren's syndrome and comparison patients (1.77% vs. 1.22%, p < 0.001). The odds ratio for head and neck cancers for patients with Sjögren's syndrome relative to the comparison group was 1.452 (95% CI = 1.325-1.592).
CONCLUSIONS
Our study demonstrated that patients with Sjögren's syndrome face increased odds of head and neck cancers, encompassing several sites including the oral cavity, oropharynx, nasopharynx, and thyroid.
目的
本研究旨在利用基于人群的数据集，调查干燥综合征患者和非干燥综合征患者头颈癌的患病率。
方法
我们从台湾纵向健康保险数据库中检索抽样患者。本研究纳入了38930例干燥综合征患者和155720例倾向评分匹配的非干燥综合征对照患者。
结果
卡方检验显示，干燥综合征患者和对照患者之间头颈癌患病率存在统计学显著差异（1.77%对1.22%，p<0.001）。干燥综合征患者患头颈癌的优势比相对于对照组为1.452（95%CI=1.325-1.592）。
结论
我们的研究表明，干燥综合征患者患头颈癌的几率增加，包括口腔、口咽、鼻咽和甲状腺等多个部位。
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