Department of Cardiology, The Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, China.
Department of Cardiology, Shenzhen Luohu Hospital Group Luohu People's Hospital (The Third Affiliated Hospital of Shenzhen University), Shenzhen, China.
BMC Cardiovasc Disord. 2024 Jan 19;24(1):60. doi: 10.1186/s12872-024-03722-4.
The triglyceride glucose-body mass index (TyG-BMI index) has been suggested as a novel predictor of insulin resistance. However, its predictive value for slow coronary flow phenomenon (SCFP) in patients with ischemia and nonobstructive coronary arteries (INOCA) remains unclear.
We consecutively recruited 1625 patients with INOCA from February 2019 to February 2023 and divided them into two groups based on thrombolysis in myocardial infarction (TIMI) frame counts (TFCs): the SCFP group (n = 79) and the control group. A 1:2 age-matched case-control study was then performed. The TyG-BMI index was calculated as ln [plasma triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI.
TyG-BMI index in the SCFP group (218.3 ± 25.2 vs 201.0 ± 26.5, P < .001) was significantly higher than in the normal controls. TyG-BMI index also increased with the number of coronary arteries involved in the SCFP. Multivariate logistic regression analysis showed that TyG-BMI, BMI, and TG were independent predictors for SCFP. Receiver operating characteristic (ROC) curve analysis showed that when the TyG-BMI index was above 206.7, the sensitivity and specificity were 88.6% and 68.5%, respectively, with an AUC of 0.809 (95% CI: 0.756-0.863, P = .027). Combined BMI with TG, the TyG-BMI index had a better predictive value for SCFP than BMI and TG (P < .001).
The TyG-BMI index was an independent predictor for SCFP in INOCA patients, and it had a better predictive value than BMI and TG.
三酰甘油-葡萄糖-体重指数（TyG-BMI 指数）已被认为是胰岛素抵抗的一种新的预测指标。然而，其对缺血且非阻塞性冠状动脉疾病（INOCA）患者慢血流现象（SCFP）的预测价值尚不清楚。
我们连续招募了 2019 年 2 月至 2023 年 2 月期间 1625 例 INOCA 患者，并根据心肌梗死溶栓治疗（TIMI）帧数（TFC）将其分为两组：SCFP 组（n=79）和对照组。然后进行了 1:2 年龄匹配的病例对照研究。TyG-BMI 指数计算为 ln[血浆三酰甘油（mg/dL）×空腹血糖（mg/dL）/2]×BMI。
SCFP 组的 TyG-BMI 指数（218.3±25.2 比 201.0±26.5，P<0.001）明显高于正常对照组。TyG-BMI 指数也随着 SCFP 受累冠状动脉数量的增加而增加。多变量逻辑回归分析显示，TyG-BMI、BMI 和 TG 是 SCFP 的独立预测因子。受试者工作特征（ROC）曲线分析显示，当 TyG-BMI 指数高于 206.7 时，敏感性和特异性分别为 88.6%和 68.5%，曲线下面积为 0.809（95%CI：0.756-0.863，P=0.027）。将 BMI 与 TG 相结合，TyG-BMI 指数对 SCFP 的预测价值优于 BMI 和 TG（P<0.001）。
TyG-BMI 指数是 INOCA 患者 SCFP 的独立预测因子，其预测价值优于 BMI 和 TG。
