Department of Cardiology, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.
Eur Rev Med Pharmacol Sci. 2024 Apr;28(8):3016-3023. doi: 10.26355/eurrev_202404_36015.
The triglyceride-glucose index (TyG) has been proposed as a marker of insulin resistance (IR) and has shown associations with cardiovascular diseases. This study aimed to investigate the relationship between the TyG and the coronary slow flow phenomenon (CSFP) and explore the index's potential as a predictor of this condition.
A total of 187 patients who underwent coronary angiography were included; of these, 91 patients were diagnosed with CSFP, and 96 patients with normal coronary flow served as a control group. The TyG was calculated using fasting triglyceride and glucose levels.
The results showed that the TyG was significantly higher in the CSFP group compared with the control group (p < 0.001). Additionally, the TyG exhibited a moderate positive correlation with the thrombolysis-in-myocardial-infarction frame count in coronary arteries (p < 0.001). A multivariate logistic regression analysis revealed that the TyG, along with gender, ejection fraction, and uric acid, remained significant predictors of CSFP (p < 0.05).
This study's findings suggest that the TyG may serve as a useful marker for identifying individuals at risk of CSFP and provide insights into the potential role of IR in its pathophysiology.
三酰甘油-葡萄糖指数（TyG）已被提出作为胰岛素抵抗（IR）的标志物，并与心血管疾病有关。本研究旨在探讨 TyG 与冠状动脉慢血流现象（CSFP）之间的关系，并探讨该指数作为预测该疾病的潜在可能性。
共纳入 187 名接受冠状动脉造影的患者；其中，91 名患者被诊断为 CSFP，96 名冠状动脉血流正常的患者作为对照组。TyG 通过空腹三酰甘油和血糖水平计算得出。
结果表明，CSFP 组的 TyG 明显高于对照组（p<0.001）。此外，TyG 与冠状动脉内血栓溶解-心肌梗死帧数呈中度正相关（p<0.001）。多变量逻辑回归分析表明，TyG 与性别、射血分数和尿酸一起仍然是 CSFP 的显著预测因子（p<0.05）。
本研究结果表明，TyG 可能是识别 CSFP 风险个体的有用标志物，并深入了解 IR 在其病理生理学中的潜在作用。
