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参术痛止方通过下调 NF-κB 信号通路和炎症反应对椎间盘退变的保护作用。

Protective effects of Shensuitongzhi formula on intervertebral disc degeneration via downregulation of NF-κB signaling pathway and inflammatory response.

机构信息

Institute of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.

The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

出版信息

J Orthop Surg Res. 2024 Jan 19;19(1):80. doi: 10.1186/s13018-023-04391-3.

DOI:10.1186/s13018-023-04391-3
PMID:38243334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10799454/
Abstract

Low back pain (LBP) is a common orthopedic disease over the world. Lumbar intervertebral disc degeneration (IDD) is regarded as an important cause of LBP. Shensuitongzhi formula (SSTZF) is a drug used in clinical treatment for orthopedic diseases. It has been found that SSTZF can have a good treatment for IDD. But the exact mechanism has not been clarified. The results showed that SSTZF protects against LSI-induced degeneration of cartilage endplates and intervertebral discs. Meanwhile, SSTZF treatment dramatically reduces the expression of inflammatory factor as well as the expression of catabolism protein and upregulates the expression of anabolism protein in LSI-induced mice. In addition, SSTZF delayed the progression of LSI-induced IDD via downregulation the level of NF-κB signaling key gene RELA and phosphorylation of key protein P65 in endplate chondrocytes. Our study has illustrated the treatment as well as the latent mechanism of SSTZF in IDD.

摘要

下背痛（LBP）是全球常见的骨科疾病。腰椎间盘退变（IDD）被认为是 LBP 的重要原因。身痛逐瘀汤方（SSTZF）是一种用于骨科疾病临床治疗的药物。已经发现 SSTZF 对 IDD 有很好的治疗作用。但其确切机制尚不清楚。结果表明，SSTZF 可防止 LSI 诱导的软骨终板和椎间盘退变。同时，SSTZF 治疗可显著降低 LSI 诱导的小鼠中炎症因子以及分解代谢蛋白的表达，并上调合成代谢蛋白的表达。此外，SSTZF 通过下调终板软骨细胞中 NF-κB 信号关键基因 RELA 和关键蛋白 P65 的磷酸化水平，延缓了 LSI 诱导的 IDD 的进展。本研究阐明了 SSTZF 在 IDD 中的治疗作用及其潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/a53a65fe14de/13018_2023_4391_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/93397b22aec1/13018_2023_4391_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/02222bac305b/13018_2023_4391_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/70e7c5b29933/13018_2023_4391_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/dc52a2f1d48b/13018_2023_4391_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/5fa1f7866ef7/13018_2023_4391_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/30789d41afe1/13018_2023_4391_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/a53a65fe14de/13018_2023_4391_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/93397b22aec1/13018_2023_4391_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/02222bac305b/13018_2023_4391_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/70e7c5b29933/13018_2023_4391_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/dc52a2f1d48b/13018_2023_4391_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/5fa1f7866ef7/13018_2023_4391_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/30789d41afe1/13018_2023_4391_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/290a/10799454/a53a65fe14de/13018_2023_4391_Fig7_HTML.jpg

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引用本文的文献

[1]
From structure to therapy: the critical influence of cartilaginous endplates and microvascular network on intervertebral disc degeneration.

Front Bioeng Biotechnol. 2024-10-28

本文引用的文献

[1]
The role of biomechanical factors in models of intervertebral disc degeneration across multiple length scales.

APL Bioeng. 2023-5-8

[2]
Deep-learning-based biomarker of spinal cartilage endplate health using ultra-short echo time magnetic resonance imaging.

Quant Imaging Med Surg. 2023-5-1

[3]
Association between clinical findings and the presence of lumbar spine osteoarthritis imaging features: A systematic review.

Osteoarthritis Cartilage. 2023-9

[4]
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).

J Orthop Translat. 2023-3-3

[5]
Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs.

Mediators Inflamm. 2023

[6]
Critical Roles of NF-κB Signaling Molecules in Bone Metabolism Revealed by Genetic Mutations in Osteopetrosis.

Int J Mol Sci. 2022-7-20

[7]
Efficacy and Safety of Bushen Huoxue Formula in Patients with Discogenic Low-Back Pain: A Double-Blind, Randomized, Placebo-Controlled Trial.

Chin J Integr Med. 2022-11

[8]
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.

J Nanobiotechnology. 2021-9-6

[9]
NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration.

Cell Prolif. 2021-7

[10]
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.

Drug Des Devel Ther. 2020

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