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High Daily Diastolic Blood Pressure Predicts Incident Stroke, Lacune, and Cerebral Microbleeds in CADASIL.

作者信息

Chen Chih-Hao, Liao Yi-Chu, Cheng Yu-Wen, Chung Chih-Ping, Lee Yi-Chung, Tang Sung-Chun

机构信息

Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.

出版信息

J Stroke. 2024 Jan;26(1):112-115. doi: 10.5853/jos.2023.02880. Epub 2024 Jan 22.

DOI:10.5853/jos.2023.02880
PMID:38246720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10850452/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d3/10850452/9ce503168753/jos-2023-02880f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d3/10850452/9ce503168753/jos-2023-02880f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d3/10850452/9ce503168753/jos-2023-02880f1.jpg

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1
High Daily Diastolic Blood Pressure Predicts Incident Stroke, Lacune, and Cerebral Microbleeds in CADASIL.每日舒张压高可预测伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）患者发生中风、腔隙性脑梗死和脑微出血。
J Stroke. 2024 Jan;26(1):112-115. doi: 10.5853/jos.2023.02880. Epub 2024 Jan 22.
2
Cerebral Microbleeds and the Risk of Incident Ischemic Stroke in CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy).CADASIL 患者脑微出血与缺血性卒中事件风险的相关性研究（伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病）。
Stroke. 2017 Oct;48(10):2699-2703. doi: 10.1161/STROKEAHA.117.017839. Epub 2017 Aug 25.
3
Cerebral microbleeds in CADASIL.伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病中的脑微出血
Neurology. 2001 Sep 25;57(6):1066-70. doi: 10.1212/wnl.57.6.1066.
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Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL.血浆神经丝轻链和胶质纤维酸性蛋白可预测 CADASIL 中的卒中。
J Neuroinflammation. 2020 Apr 22;17(1):124. doi: 10.1186/s12974-020-01813-5.
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Clinical significance of cerebral microbleeds locations in CADASIL with R544C NOTCH3 mutation.携带R544C NOTCH3突变的大脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）中脑微出血部位的临床意义
PLoS One. 2015 Feb 18;10(2):e0118163. doi: 10.1371/journal.pone.0118163. eCollection 2015.
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Effect of EGFr Group, Sex, and Cardiovascular Risk Factors on CADASIL Clinical and Neuroimaging Outcomes.EGFr 组、性别和心血管危险因素对 CADASIL 临床和神经影像学结局的影响。
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Clinical correlates of longitudinal MRI changes in CADASIL.CADASIL 患者纵向 MRI 变化的临床相关性。
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Neurology. 2023 Oct 24;101(17):e1665-e1677. doi: 10.1212/WNL.0000000000207713. Epub 2023 Aug 31.

引用本文的文献

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Vascular NOTCH3 Deposition Load: Association With Genotype and CADASIL Disease Severity.血管性NOTCH3沉积负荷：与基因型及CADASIL疾病严重程度的关联
Neurol Genet. 2025 Aug 27;11(5):e200288. doi: 10.1212/NXG.0000000000200288. eCollection 2025 Oct.
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Characteristics and temporal evolution of asymptomatic diffusion-weighted imaging lesions in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).伴皮质下梗死和白质脑病的脑常染色体显性遗传性动脉病（CADASIL）患者无症状性弥散加权成像病变的特征及其时间演变。
Eur J Neurol. 2024 Dec;31(12):e16519. doi: 10.1111/ene.16519. Epub 2024 Oct 11.

本文引用的文献

1
Isolated Diastolic Hypertension and Risk of Cardiovascular Events: A Systematic Review and Meta-Analysis of Cohort Studies With 489,814 Participants.单纯舒张期高血压与心血管事件风险：对489,814名参与者的队列研究进行的系统评价和荟萃分析
Front Cardiovasc Med. 2022 Jan 5;8:810105. doi: 10.3389/fcvm.2021.810105. eCollection 2021.
2
Age and Diastolic Blood Pressure Play an Important Role in the Progression of White Matter Lesions: A Meta-Analysis.年龄和舒张压在脑白质病变进展中起着重要作用：一项荟萃分析。
Eur Neurol. 2020;83(4):351-359. doi: 10.1159/000510077. Epub 2020 Sep 9.
3
Blood Pressure Variability and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis of Population-Based Cohorts.
血压变异性与脑小血管病：基于人群队列的系统评价和荟萃分析。
Stroke. 2020 Jan;51(1):82-89. doi: 10.1161/STROKEAHA.119.026739. Epub 2019 Nov 27.
4
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.收缩压和舒张压对心血管结局的影响。
N Engl J Med. 2019 Jul 18;381(3):243-251. doi: 10.1056/NEJMoa1803180.
5
Ambulatory blood pressure in patients with lacunar stroke: association with total MRI burden of cerebral small vessel disease.腔隙性卒中患者的动态血压：与脑小血管病总 MRI 负荷的相关性。
Stroke. 2013 Nov;44(11):2995-9. doi: 10.1161/STROKEAHA.113.002545. Epub 2013 Aug 27.
6
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.神经影像学标准研究小血管疾病及其对衰老和神经退行性变的影响。
Lancet Neurol. 2013 Aug;12(8):822-38. doi: 10.1016/S1474-4422(13)70124-8.
7
Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.脑小血管病：从发病机制和临床特征到治疗挑战。
Lancet Neurol. 2010 Jul;9(7):689-701. doi: 10.1016/S1474-4422(10)70104-6.
8
Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort study.血压和糖化血红蛋白与伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病中的微出血相关：一项双中心队列研究。
Brain. 2006 Sep;129(Pt 9):2375-83. doi: 10.1093/brain/awl177. Epub 2006 Jul 14.
9
Brain volume changes in CADASIL: a serial MRI study in pure subcortical ischemic vascular disease.伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）的脑容量变化：一项关于纯皮质下缺血性血管病的系列磁共振成像研究
Neurology. 2006 May 23;66(10):1517-22. doi: 10.1212/01.wnl.0000216271.96364.50.
10
Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study.扩散磁共振直方图作为大脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）疾病进展的替代标志物和预测指标：一项为期两年的随访研究。
Stroke. 2005 Dec;36(12):2559-65. doi: 10.1161/01.STR.0000189696.70989.a4. Epub 2005 Nov 3.