Fogh S, Jepsen S, Effersøe P
Trans R Soc Trop Med Hyg. 1979;73(2):228-9. doi: 10.1016/0035-9203(79)90220-7.
A case of chloroquine-resistant Plasmodium falciparum malaria in a non-immune male is reported. Primary attack came 19 days after return to a non-malarious country from a visit to Kenya. Recrudescences occurred three times with intervals of 30 to 33 days after standard chloroquine treatment. The WHO extended field test for sensitivity of falciparum malaria to chloroquine was followed by recrudescence 31 days later. Treatment with Fansidar terminated the infection. If continuous treatment of the patient with lithium does not interfere with the schizontocidal action of chloroquine, this strain shows a resistance pattern of R I delayed recrudescence.
报告了一例非免疫男性感染氯喹耐药恶性疟原虫疟疾的病例。该患者从肯尼亚回国前往一个无疟疾国家19天后首次发病。在接受标准氯喹治疗后，病情复发了三次，间隔时间为30至33天。按照世界卫生组织对恶性疟原虫对氯喹敏感性的扩展现场试验方法进行治疗后，31天后病情复发。使用Fansidar治疗使感染得到控制。如果对该患者持续使用锂治疗不干扰氯喹的杀裂殖体作用，那么该菌株表现出RI延迟复发的耐药模式。
