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特罗勒德静脉血栓形成:蛋白C缺乏症的非典型表现。

Thrombosis of the Vein of Trolard: An Atypical Presentation of Protein C Deficiency.

作者信息

Waqas Zeeshan, Rahman Saima, Khan Sajid, Khan Arooba, Ali Yasir, Haider Iqbal

机构信息

Internal Medicine, Khyber Teaching Hospital, Peshawar, PAK.

Radiology, Hayatabad Medical Complex, Peshawar, PAK.

出版信息

Cureus. 2023 Dec 22;15(12):e50943. doi: 10.7759/cureus.50943. eCollection 2023 Dec.

Abstract

Cerebral venous thrombosis refers to complete or partial occlusion of the cerebral sinus/es or the feeding cortical veins, resulting in secondary effects of vascular congestion and focal or generalized neurological deficits. One of the important causes of venous thromboembolism is inherited thrombophilia. Our case is of a 34-year-old male with no previous comorbidity who presented to the emergency department with complaints of sudden onset left-sided weakness, seizures, and loss of consciousness for one day. Thrombosis of the vein of Trolard was diagnosed based on magnetic resonance venography (MRV) film. His MRI with MRV revealed an attenuated caliber of the vein of Trolard along with abnormal signal intensity in the right fronto-parietal region and the right falcine location. He was managed with intravenous medication, including levetiracetam and topiramate. Once the diagnosis was established, he was commenced on subcutaneous Enoxaparin. Consequently, his GCS improved from 6/15 to 15/15 within the first 24 hours, and he could move his limbs on the day of discharge without any significant disability.

摘要

脑静脉血栓形成是指脑静脉窦或其供血皮质静脉的完全或部分闭塞,导致血管充血及局灶性或全身性神经功能缺损的继发效应。静脉血栓栓塞的重要病因之一是遗传性易栓症。我们的病例是一名34岁男性,既往无合并症,因突发左侧肢体无力、癫痫发作及意识丧失1天就诊于急诊科。根据磁共振静脉血管造影(MRV)片子诊断为Trolard静脉血栓形成。他的MRI及MRV显示Trolard静脉管径变细,同时右侧额顶叶区域及右侧大脑镰部位信号强度异常。他接受了包括左乙拉西坦和托吡酯在内的静脉用药治疗。一旦确诊,即开始皮下注射依诺肝素。结果,他的格拉斯哥昏迷评分(GCS)在最初24小时内从6/15提高到15/15,出院当天四肢可活动,无明显残疾。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85f/10800082/4e13ce0846b3/cureus-0015-00000050943-i01.jpg

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