Suzuki Takahiro, Ishida Chiharu, Yoshioka Yoko, Kojima Masae, Tokoro Mikiko, Fukunaga Noritaka, Asada Yoshimasa
Asada Ladies Clinic Nagoya Aichi Japan.
Asada Institute for Reproductive Medicine Nagoya City Aichi Prefecture Japan.
Reprod Med Biol. 2024 Jan 18;23(1):e12560. doi: 10.1002/rmb2.12560. eCollection 2024 Jan-Dec.
The primary objective of this investigation is to evaluate how morphological quality affects the pregnancy outcomes in euploid embryos determined by preimplantation genetic testing for aneuploidies (PGT-A). Concurrently, as a secondary objective, we aim to identify which specific aspects of morphological evaluation exert the most significant impact on these outcomes.
A retrospective analysis of 451 single euploid embryo transfer cycles at our clinic was conducted. Embryos were evaluated based on the degree of blastocyst expansion, inner cell mass (ICM), trophectoderm (TE) morphology, and the day of blastocyst vitrification. Outcomes between morphologically low-grade and high-grade embryos were compared. Additionally, the study analyzed which morphological factors most influenced pregnancy outcomes.
Pregnancy outcomes were significantly lower in morphologically low-grade blastocysts compared to high-grade ones. Among the morphological evaluations, the ICM assessment was significantly associated with the live birth rate.
Our study indicates that the morphological quality of euploid embryos, particularly the evaluation of the ICM, plays a crucial role in IVF-ET success.
本研究的主要目的是评估形态学质量如何影响通过胚胎植入前非整倍体基因检测（PGT-A）确定的整倍体胚胎的妊娠结局。同时，作为次要目的，我们旨在确定形态学评估的哪些具体方面对这些结局影响最大。
对我们诊所451个单整倍体胚胎移植周期进行回顾性分析。根据囊胚扩张程度、内细胞团（ICM）、滋养外胚层（TE）形态以及囊胚玻璃化日期对胚胎进行评估。比较形态学低级别和高级别胚胎的结局。此外，该研究分析了哪些形态学因素对妊娠结局影响最大。
形态学低级别囊胚的妊娠结局显著低于高级别囊胚。在形态学评估中，ICM评估与活产率显著相关。
我们的研究表明，整倍体胚胎的形态学质量，特别是ICM评估，在体外受精-胚胎移植成功中起着关键作用。
