Wang Shijin, Qi Xiaochen, Liu Dequan, Xie Deqian, Jiang Bowen, Wang Jin, Wang Xiaoxi, Wu Guangzhen
Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.
Comput Struct Biotechnol J. 2023 Dec 20;23:491-505. doi: 10.1016/j.csbj.2023.12.016. eCollection 2024 Dec.
Urological malignancies are a major global health issue because of their complexity and the wide range of ways they affect patients. There's a growing need for in-depth research into these cancers, especially at the molecular level. Recent studies have highlighted the importance of non-coding RNAs (ncRNAs) – these don't code for proteins but are crucial in controlling genes – and the tumor microenvironment (TME), which is no longer seen as just a background factor but as an active player in cancer progression. Understanding how ncRNAs and the TME interact is key for finding new ways to diagnose and predict outcomes in urological cancers, and for developing new treatments. This article reviews the basic features of ncRNAs and goes into detail about their various roles in the TME, focusing specifically on how different ncRNAs function and act in urological malignancies.
泌尿外科恶性肿瘤是一个重大的全球健康问题，因其复杂性以及对患者产生影响的广泛方式。对这些癌症进行深入研究的需求日益增长，尤其是在分子层面。最近的研究强调了非编码RNA（ncRNAs）的重要性——这些RNA不编码蛋白质，但在控制基因方面至关重要——以及肿瘤微环境（TME），肿瘤微环境不再仅仅被视为一个背景因素，而是被看作癌症进展中的一个积极参与者。了解ncRNAs与TME如何相互作用是寻找泌尿外科癌症新的诊断和预测结果方法以及开发新治疗方法的关键。本文回顾了ncRNAs的基本特征，并详细阐述了它们在TME中的各种作用，特别关注不同的ncRNAs在泌尿外科恶性肿瘤中的功能和作用方式。
