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核壳结构FeO@C纳米颗粒作为高效的T磁共振成像造影剂：体外和体内研究

Core-Shell FeO@C Nanoparticles as Highly Effective T Magnetic Resonance Imaging Contrast Agents: In Vitro and In Vivo Studies.

作者信息

Yue Huan, Zhao Dejun, Tegafaw Tirusew, Ahmad Mohammad Yaseen, Saidi Abdullah Khamis Ali Al, Liu Ying, Cha Hyunsil, Yang Byeong Woo, Chae Kwon Seok, Nam Sung-Wook, Chang Yongmin, Lee Gang Ho

机构信息

Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.

Division of Biomedical Science, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea.

出版信息

Nanomaterials (Basel). 2024 Jan 12;14(2):177. doi: 10.3390/nano14020177.

DOI:10.3390/nano14020177
PMID:38251140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10819740/
Abstract

Magnetite nanoparticles (FeO NPs) have been intensively investigated because of their potential biomedical applications due to their high saturation magnetization. In this study, core-shell FeO@C NPs (core = FeO NPs and shell = amorphous carbons, d = 35.1 nm) were synthesized in an aqueous solution. Carbon coating terminated with hydrophilic -OH and -COOH groups imparted excellent biocompatibility and hydrophilicity to the NPs, making them suitable for biomedical applications. The FeO@C NPs exhibited ideal relaxometric properties for T magnetic resonance imaging (MRI) contrast agents (i.e., high transverse and negligible longitudinal water proton spin relaxivities), making them exclusively induce only T relaxation. Their T MRI performance as contrast agents was confirmed in vivo by measuring T MR images in mice before and after intravenous injection.

摘要

由于具有高饱和磁化强度，磁铁矿纳米颗粒（FeO NPs）因其潜在的生物医学应用而受到广泛研究。在本研究中，在水溶液中合成了核壳结构的FeO@C NPs（核 = FeO NPs，壳 = 无定形碳，d = 35.1 nm）。以亲水性 -OH 和 -COOH 基团封端的碳涂层赋予了纳米颗粒优异的生物相容性和亲水性，使其适用于生物医学应用。FeO@C NPs 作为 T 磁共振成像（MRI）造影剂表现出理想的弛豫特性（即高横向和可忽略不计的纵向水质子自旋弛豫率），使其仅能专门诱导 T 弛豫。通过测量小鼠静脉注射前后的 T MR 图像，在体内证实了它们作为造影剂的 T MRI 性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/d847a68a4a57/nanomaterials-14-00177-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/a1fae810f9c8/nanomaterials-14-00177-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/bd93a6db140e/nanomaterials-14-00177-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/a1c1e8ab0930/nanomaterials-14-00177-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/c88bd44738df/nanomaterials-14-00177-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/d6937c1be6d7/nanomaterials-14-00177-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/53f1b2ca8539/nanomaterials-14-00177-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/d847a68a4a57/nanomaterials-14-00177-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/a1fae810f9c8/nanomaterials-14-00177-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/bd93a6db140e/nanomaterials-14-00177-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/a1c1e8ab0930/nanomaterials-14-00177-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/c88bd44738df/nanomaterials-14-00177-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/d6937c1be6d7/nanomaterials-14-00177-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/53f1b2ca8539/nanomaterials-14-00177-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5889/10819740/d847a68a4a57/nanomaterials-14-00177-g007.jpg

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Core-Shell FeO@C Nanoparticles as Highly Effective T Magnetic Resonance Imaging Contrast Agents: In Vitro and In Vivo Studies.

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Adv Mater. 2023-12

[2]
Ionic liquids functionalized FeO-based colorimetric biosensor for rapid determination of ochratoxin A.

Mikrochim Acta. 2023-8-23

[3]
High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/FeO Nanoparticles.

Pharmaceutics. 2023-5-18

[4]
The State of the Art of Natural Polymer Functionalized FeO Magnetic Nanoparticle Composites for Drug Delivery Applications: A Review.

Gels. 2023-2-1

[5]
CT and MRI Imaging of Theranostic Bimodal FeO@Au NanoParticles in Tumor Bearing Mice.

Int J Mol Sci. 2022-12-21

[6]
Composite Scaffolds of Gelatin and Fe O Nanoparticles for Magnetic Hyperthermia-Based Breast Cancer Treatment and Adipose Tissue Regeneration.

Adv Healthc Mater. 2023-4

[7]
Polyetherimide- and folic acid-modified Fe O nanospheres for enhanced magnetic hyperthermia performance.

J Biomed Mater Res B Appl Biomater. 2023-4

[8]
Facile synthesis of water-soluble FeO and FeO@PVA nanoparticles for dual-contrast T1- and T2-weighted magnetic resonance imaging.

Magn Reson Imaging. 2023-1

[9]
Effect of Surface Functionalization on the Magnetization of FeO Nanoparticles by Hybrid Density Functional Theory Calculations.

J Phys Chem Lett. 2022-10-13

[10]
FeO Nanoparticles: Structures, Synthesis, Magnetic Properties, Surface Functionalization, and Emerging Applications.

Appl Sci (Basel). 2021-12

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