2,5A的虫草素类似物及其苏式异构体。化学合成、构象与生物活性。
The cordycepin analogue of 2,5A and its threo isomer. Chemical synthesis, conformation and biological activity.
作者信息
Nyilas A, Vrang L, Drake A, Oberg B, Chattopadhyaya J
出版信息
Acta Chem Scand B. 1986 Sep;40(8):678-88. doi: 10.3891/acta.chem.scand.40b-0678.
Abstract
A new synthesis of the cordycepin analogue of 2,5A and its threo isomer is reported along with an assessment of their conformations by circular dichroism spectroscopy. Evidence is also presented showing that these compounds are stable against 2,5A-specific phosphodiesterase and are not able to activate the 2,5A-dependent endoribonuclease, possibly due to a reduced binding to the latter enzyme as compared to that of 2,5A.
摘要
报道了2,5A虫草素类似物及其苏式异构体的一种新合成方法，并通过圆二色光谱对其构象进行了评估。还提供了证据表明这些化合物对2,5A特异性磷酸二酯酶具有稳定性，并且不能激活2,5A依赖性核糖核酸酶，这可能是由于与2,5A相比，它们与后一种酶的结合减少。
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