生物活性寡脱氧核糖核苷酸。10：含甘油骨架的修饰六核苷酸的抗HIV-1活性及稳定性
Biologically active oligodeoxyribonucleotides. 10: anti-HIV-1 activity and stability of modified hexanucleotides containing glycerol-skeleton.
作者信息
Hotoda H, Koizumi M, Ohmine T, Furukawa H, Nishigaki T, Abe K, Kosaka T, Tsutsumi S, Sone J, Kaneko M
机构信息
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
出版信息
Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):243-52. doi: 10.1080/07328319808005173.
PMID:9708349
Abstract
Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which exhibits anti-HIV-1 activity, were partially replaced with glycerol-moieties. Compound 7 with two glycerylguanines at its 3'-end showed more potent anti-HIV-1 activity and more stability against digestion by nucleases than the parent compound 1.
摘要
具有抗HIV-1活性的修饰十六脱氧核糖核苷酸1的脱氧核糖部分被甘油部分部分取代。在其3'-末端带有两个甘油基鸟嘌呤的化合物7比母体化合物1表现出更强的抗HIV-1活性和对核酸酶消化的更高稳定性。
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