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同种异体和异种外泌体治疗犬特应性皮炎的疗效：一项初步研究。

Efficacy of Allogeneic and Xenogeneic Exosomes for the Treatment of Canine Atopic Dermatitis: A Pilot Study.

作者信息

Kim Sang-Won, Lim Kyung-Min, Cho Ssang-Goo, Ryu Bokyeong, Kim C-Yoon, Park Seon Young, Jang Kyungmin, Jung Jae Heon, Park Cheolhyoung, Choi Chulhee, Kim Jung-Hyun

机构信息

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.

Department of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center and Institute of Advanced Regenerative Science, Konkuk University, Seoul 05029, Republic of Korea.

出版信息

Animals (Basel). 2024 Jan 16;14(2):282. doi: 10.3390/ani14020282.

DOI:10.3390/ani14020282
PMID:38254451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10812568/
Abstract

Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory pruritic skin disease. The available treatments for CAD have several adverse effects and vary in efficacy, indicating the need for the development of improved treatments. In this study, we aimed to elucidate the therapeutic effects of allogeneic and xenogeneic exosomes on CAD. Six laboratory beagle dogs with CAD were randomly assigned to three treatment groups: control, canine exosome (cExos), or human exosome (hExos) groups. Dogs in the cExos and hExos groups were intravenously administered 1.5 mL of cExos (5 × 10) and hExos (7.5 × 10) solutions, respectively, while those in the control group were administered 1.5 mL of normal saline three times per week for 4 weeks. Skin lesion score and transepidermal water loss decreased in cExos and hExos groups compared with those in the control group. The exosome treatments decreased the serum levels of inflammatory cytokines (interferon-γ, interleukin-2, interleukin-4, interleukin-12, interleukin-13, and interleukin-31) but increased those of anti-inflammatory cytokines (interleukin-10 and transforming growth factor-β), indicating the immunomodulatory effect of exosomes. Skin microbiome analysis revealed that the exosome treatments alleviated skin bacterial dysbiosis. These results suggest that allogeneic and xenogeneic exosome therapy may alleviate CAD in dogs.

摘要

犬特应性皮炎（CAD）是一种具有遗传易感性的炎症性瘙痒性皮肤病。现有的CAD治疗方法有多种不良反应且疗效各异，这表明需要开发更好的治疗方法。在本研究中，我们旨在阐明同种异体和异种外泌体对CAD的治疗效果。六只患有CAD的实验比格犬被随机分为三个治疗组：对照组、犬外泌体（cExos）组或人外泌体（hExos）组。cExos组和hExos组的犬分别静脉注射1.5 mL的cExos（5×10）和hExos（7.5×10）溶液，而对照组的犬每周三次静脉注射1.5 mL生理盐水，共4周。与对照组相比，cExos组和hExos组的皮肤病变评分和经表皮水分流失降低。外泌体治疗降低了炎症细胞因子（干扰素-γ、白细胞介素-2、白细胞介素-4、白细胞介素-12、白细胞介素-13和白细胞介素-31）的血清水平，但提高了抗炎细胞因子（白细胞介素-10和转化生长因子-β）的血清水平，表明外泌体具有免疫调节作用。皮肤微生物组分析显示，外泌体治疗减轻了皮肤细菌生态失调。这些结果表明，同种异体和异种外泌体疗法可能减轻犬的CAD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/021747567501/animals-14-00282-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/fd71b7faa6e4/animals-14-00282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/a054c065a24f/animals-14-00282-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/5a565f50b1bb/animals-14-00282-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/c1479af016c3/animals-14-00282-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/43d44f9200be/animals-14-00282-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/3dc8d2f95600/animals-14-00282-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/021747567501/animals-14-00282-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/fd71b7faa6e4/animals-14-00282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/a054c065a24f/animals-14-00282-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/5a565f50b1bb/animals-14-00282-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/c1479af016c3/animals-14-00282-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/43d44f9200be/animals-14-00282-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/3dc8d2f95600/animals-14-00282-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9f/10812568/021747567501/animals-14-00282-g007.jpg

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