Stich Ashley N, Rosenkrantz Wayne S, Griffin Craig E
Animal Dermatology Clinic, 2965 Edinger Avenue, Tustin, CA, 92780, USA.
Vet Dermatol. 2014 Oct;25(5):464-e74. doi: 10.1111/vde.12144. Epub 2014 Jun 9.
Canine atopic dermatitis is a genetically predisposed inflammatory skin disease often requiring multimodal treatment. There is a need to find further low-risk adjunctive therapies.
HYPOTHESIS/OBJECTIVES: To evaluate the localized effect of low-level laser therapy (LLLT) on the paws of dogs with atopic dermatitis using a localized canine atopic dermatitis severity score (LCADSS) and owner localized pruritic visual analog score (LPVAS) in comparison to treatment with a placebo.
Thirty client-owned dogs with symmetrical pedal pruritus due to canine atopic dermatitis.
Dogs were randomly assigned into two groups. In each group, one paw was treated with LLLT and one paw treated with a placebo laser (comparing either both fore- or hindpaws). Treatments were administered at 4 J/cm(2) (area from carpus/tarsus to distal aspect of digit 3) three times per week for the first 2 weeks and two times per week for the second 2 weeks. Scores were assessed for each paw at weeks 0, 2, 4 and 5.
There were no significant differences in LCADSS or LPVAS between LLLT and placebo treatments between weeks 0 and 5 (P = 0.0856 and 0.5017, respectively). However, LCADSS and LPVAS significantly decreased from week 0 at weeks 2, 4 and 5 in both LLLT and placebo groups (P < 0.0001 for all).
Low-level laser therapy is not an effective localized treatment for pedal pruritus in canine atopic dermatitis.
犬特应性皮炎是一种具有遗传易感性的炎症性皮肤病，通常需要多模式治疗。有必要寻找更多低风险的辅助治疗方法。
假设/目的：使用局部犬特应性皮炎严重程度评分（LCADSS）和主人局部瘙痒视觉模拟评分（LPVAS），评估低强度激光治疗（LLLT）对患有特应性皮炎的犬爪部的局部效果，并与安慰剂治疗进行比较。
30只因犬特应性皮炎而出现对称性足部瘙痒的客户拥有的犬。
将犬随机分为两组。在每组中，一只爪用LLLT治疗，另一只爪用安慰剂激光治疗（比较前爪或后爪）。在前2周每周3次以4 J/cm²（从腕关节/跗关节到第3趾远端的区域）进行治疗，后2周每周2次。在第0、2、4和5周对每只爪进行评分。
在第0至5周期间，LLLT和安慰剂治疗之间的LCADSS或LPVAS没有显著差异（分别为P = 0.0856和0.5017）。然而，在LLLT组和安慰剂组中，LCADSS和LPVAS在第2、4和5周时均较第0周显著降低（所有P < 0.0001）。
低强度激光治疗不是犬特应性皮炎足部瘙痒的有效局部治疗方法。
