Villena-Salinas Javier, Ortega-Lozano Simeón José, Amrani-Raissouni Tomader, Agüera-Morales Eduardo, Caballero-Villarraso Javier
Nuclear Medicine Service, Virgen de la Victoria University Hospital, 29010 Málaga, Spain.
Neurology Service, Reina Sofia University Hospital, 14004 Cordoba, Spain.
Biomedicines. 2024 Jan 3;12(1):102. doi: 10.3390/biomedicines12010102.
Multiple system atrophy (MSA) is a neurodegenerative disease. It has a fast progression, so early diagnosis is decisive. Two functional imaging tests can be involved in its diagnosis: [I]Ioflupane SPECT and [I]MIBG scintigraphy. Our aim is to comparatively analyze the diagnostic performance of both techniques.
46 patients (24 males and 22 females) with MSA underwent [I]Ioflupane SPECT and [I]MIBG scintigraphy. In each of these techniques, qualitative assessment was compared with quantitative assessment.
SPECT visual assessment was positive in 93.5% of subjects (S = 95.24%; PPV = 93.02%). A cut-off of 1.363 was established for overall S/O index (S = 85.7%, E = 100%). Visual assessment of scintigraphy was positive in 73.1% (S = 78.57%, PPV = 94.29%). For the delayed heart/medistinum ratio (HMR) a cut-off of 1.43 (S = 85.3, E = 100%) was obtained. For each unit increase in delayed HMR, the suspicion of MSA increased by 1.58 (OR = 1.58, < 0.05). The quantitative assessment showed an association with the visual assessment for each technique ( < 0.05).
Both tests are useful in MSA diagnosis. Comparatively, we did not observe a clear superiority of either. Striatal and myocardial deterioration do not evolve in parallel. Qualitative assessment is crucial in both techniques, together with the support of quantitative analysis. Delayed HMR shows a direct relationship with the risk of MSA.
多系统萎缩（MSA）是一种神经退行性疾病。其病情进展迅速，因此早期诊断至关重要。两种功能成像检查可用于其诊断：[I]碘氟潘单光子发射计算机断层扫描（SPECT）和[I]间碘苄胍闪烁扫描术。我们的目的是比较分析这两种技术的诊断性能。
46例多系统萎缩患者（24例男性和22例女性）接受了碘氟潘SPECT和间碘苄胍闪烁扫描术检查。在每种技术中，将定性评估与定量评估进行了比较。
SPECT视觉评估在93.5%的受试者中呈阳性（敏感度=95.
