Tomić Tanja, Tomić Davor, Vukoja Martina, Kraljević Marija, Ljevak Ivona, Glamočlija Una, Tomić Vajdana, Vukojević Katarina, Beljan Perak Renata, Šoljić Violeta
Faculty of Health Studies, University of Mostar, Bijeli Brijeg bb, 88000 Mostar, Bosnia and Herzegovina.
Department of Urology, University Hospital Center Mostar, Bijeli Brijeg bb, 88000 Mostar, Bosnia and Herzegovina.
Biomedicines. 2024 Jan 10;12(1):149. doi: 10.3390/biomedicines12010149.
While clear cell renal cell carcinoma (ccRCC) is curable, advanced metastatic (mRCC) remains a clinical challenge. We analyzed clinical, pathohistological, and molecular data (Receptor Interacting Protein 5-RIP5 and Vestigial Like Family Member 4-VGLL4 expression) of 55 mRCC patients treated with first-line treatment with sunitinib. The trend of linear increase in the protein expression of RIP5 was observed with the progression of tumor grade. Overall, 80% of RIP5-positive cells were in the control kidneys and high-grade mRCC. On the contrary, RIP5 displayed low expression in grade 2 mRCC (5.63%). The trend of linear decrease in the expression of VGLL4 was observed with the progression of tumor grade. The highest protein expression of VGLL4 was observed in grade 2 (87.82%) in comparison to grade 3 and 4 and control. High expression of RIP5 mRNA was associated with longer first-line overall survival and longer progression-free survival in mRCC. In addition, a high VGLL4 mRNA expression showed better overall survival in patients with ccRCC. In conclusion, high mRNA expression of RIP5 and VGLL4 are important markers of better survival rates in mRCC patients.
虽然透明细胞肾细胞癌（ccRCC）是可治愈的，但晚期转移性肾细胞癌（mRCC）仍然是一项临床挑战。我们分析了55例接受舒尼替尼一线治疗的mRCC患者的临床、病理组织学和分子数据（受体相互作用蛋白5-RIP5和类 vestigial 家族成员4-VGLL4表达）。随着肿瘤分级的进展，观察到RIP5蛋白表达呈线性增加趋势。总体而言，80%的RIP5阳性细胞存在于对照肾脏和高级别mRCC中。相反，RIP5在2级mRCC中表达较低（5.63%）。随着肿瘤分级的进展，观察到VGLL4表达呈线性下降趋势。与3级、4级及对照相比，VGLL4蛋白表达在2级中最高（87.82%）。RIP5 mRNA高表达与mRCC患者一线总生存期延长和无进展生存期延长相关。此外，VGLL4 mRNA高表达在ccRCC患者中显示出更好的总生存期。总之，RIP5和VGLL4的mRNA高表达是mRCC患者生存率较高的重要标志物。
