Department of Food Analysis and Environmental Protection, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, Seminaryjna 3, 85-326 Bydgoszcz, Poland.
Molecules. 2024 Jan 12;29(2):380. doi: 10.3390/molecules29020380.
Non-steroidal anti-inflammatory drugs (NSAIDs) have been recognized as a potentially serious threat to the natural environment. NSAIDs are popular painkillers, and the main pathway for them to reach natural water is via discharge from wastewater and sewage treatment plants. In order to monitor contamination caused by these drugs, as well as their impact on the environment, a new material based on Silica Gel 60, functionalized with a dendrimeric copolymer of methylamine and 1,4-butanediol diglycidyl ether (named MA-BDDE), was prepared. Initial physicochemical characterization of the MA-BDDE material was carried out using ATR FT-IR spectroscopy as well as solid-state carbon-13 NMR spectroscopy. Its effectiveness at NSAID extraction was evaluated by the application of five select drugs in dispersive solid-phase extraction (dSPE): aspirin, ketoprofen, naproxen, diclofenac and ibuprofen. This was followed by their simultaneous determination using the HPLC-UV/Vis system demonstrating good sensitivity, with limits of detection values within the 63-265 ng mL range. A comparison of the sorption capacity of each pharmaceutical with unmodified base silica showed an at least tenfold increase in capacity after modification. Initial MA-BDDE application in a quick, low-waste extraction procedure of those select NSAIDs from spiked surface water samples yielded promising results for its use as a sorbent, as recovery values of analytes adsorbed from various samples were found to exceed 72%.
非甾体抗炎药（NSAIDs）已被认为是对自然环境的潜在严重威胁。NSAIDs 是一种常用的止痛药，它们进入自然水的主要途径是通过废水和污水处理厂的排放。为了监测这些药物造成的污染及其对环境的影响，我们制备了一种基于硅胶 60 的新材料，该材料用甲基胺和 1,4-丁二醇二缩水甘油醚的树枝状共聚物（命名为 MA-BDDE）进行了功能化。通过衰减全反射傅里叶变换红外光谱（ATR FT-IR）和固态碳-13 核磁共振光谱（NMR）对 MA-BDDE 材料进行了初步的物理化学特性表征。通过在分散固相萃取（dSPE）中应用五种选择药物（阿司匹林、酮洛芬、萘普生、双氯芬酸和布洛芬）来评估其对 NSAID 提取的效果。然后使用高效液相色谱-紫外/可见分光光度法（HPLC-UV/Vis）系统同时测定它们，该方法具有良好的灵敏度，检测限范围在 63-265ng/mL 之间。将每种药物的吸附能力与未改性的基础硅胶进行比较，发现修饰后吸附能力至少增加了十倍。MA-BDDE 最初应用于从加标地表水样品中快速、低废物提取这些选择 NSAIDs 的程序中，作为吸附剂的结果令人鼓舞，因为从各种样品中吸附的分析物的回收率超过 72%。
