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革新疟疾媒介控制:通过增强分子能力进行准确物种鉴定的重要性。

Revolutionizing Malaria Vector Control: The Importance of Accurate Species Identification through Enhanced Molecular Capacity.

作者信息

Hadebe Mzwandile Thabani, Malgwi Samson Anjikwi, Okpeku Moses

机构信息

Discipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, Westville, Durban 4000, South Africa.

出版信息

Microorganisms. 2023 Dec 31;12(1):82. doi: 10.3390/microorganisms12010082.

Abstract

Many factors, such as the resistance to pesticides and a lack of knowledge of the morphology and molecular structure of malaria vectors, have made it more challenging to eradicate malaria in numerous malaria-endemic areas of the globe. The primary goal of this review is to discuss malaria vector control methods and the significance of identifying species in vector control initiatives. This was accomplished by reviewing methods of molecular identification of malaria vectors and genetic marker classification in relation to their use for species identification. Due to its specificity and consistency, molecular identification is preferred over morphological identification of malaria vectors. Enhanced molecular capacity for species identification will improve mosquito characterization, leading to accurate control strategies/treatment targeting specific mosquito species, and thus will contribute to malaria eradication. It is crucial for disease epidemiology and surveillance to accurately identify the that are causing malaria in patients. The capacity for disease surveillance will be significantly increased by the development of more accurate, precise, automated, and high-throughput diagnostic techniques. In conclusion, although morphological identification is quick and achievable at a reduced cost, molecular identification is preferred for specificity and sensitivity. To achieve the targeted malaria elimination goal, proper identification of vectors using accurate techniques for effective control measures should be prioritized.

摘要

许多因素,如对杀虫剂的抗性以及对疟疾媒介形态学和分子结构缺乏了解,使得在全球众多疟疾流行地区根除疟疾变得更具挑战性。本综述的主要目的是讨论疟疾媒介控制方法以及在媒介控制举措中识别物种的重要性。这是通过回顾疟疾媒介的分子鉴定方法以及与用于物种鉴定相关的遗传标记分类来实现的。由于其特异性和一致性,分子鉴定比疟疾媒介的形态学鉴定更受青睐。增强物种鉴定的分子能力将改善蚊子的特征描述,从而制定针对特定蚊子种类的准确控制策略/治疗方法,进而有助于根除疟疾。准确识别导致患者患疟疾的媒介对于疾病流行病学和监测至关重要。更准确、精确、自动化和高通量诊断技术的发展将显著提高疾病监测能力。总之,虽然形态学鉴定快速且成本较低,但分子鉴定因其特异性和敏感性更受青睐。为实现目标疟疾消除目标,应优先使用准确技术正确识别媒介以采取有效的控制措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06af/10818655/fb81fe56fe2d/microorganisms-12-00082-g001.jpg

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