用于细胞因子检测的全介质超材料太赫兹生物传感器。

An All-Dielectric Metamaterial Terahertz Biosensor for Cytokine Detection.

作者信息

Men Kuo, Lian Ziwei, Tu Hailing, Zhao Hongbin, Wei Qianhui, Jin Qingxi, Mao Changhui, Wei Feng

机构信息

State Key Laboratory of Advanced Materials for Smart Sensing, GRINM Group Co., Ltd., Beijing 100088, China.

GRIMAT Engineering Institute Co., Ltd., Beijing 101402, China.

出版信息

Micromachines (Basel). 2023 Dec 26;15(1):53. doi: 10.3390/mi15010053.

DOI:10.3390/mi15010053

PMID:38258172

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10819069/

Abstract

In this paper, we report an all-dielectric metamaterial terahertz biosensor, which exhibits a high Q factor of 35 at an 0.82 resonance peak. A structure with an electromagnetically induced transparency effect was designed and fabricated to perform a Mie resonance for the terahertz response. The biosensor exhibits a limit of detection of 100 pg/mL for cytokine interleukin 2 (IL-2) and a linear response for the logarithm of the concentration of IL-2 in the range of 100 pg/mL to 1 μg/mL. This study implicates an important potential for the detection of cytokines in serum and has potential application in the clinical detection of cytokine release syndrome.

摘要

在本文中，我们报道了一种全介质超材料太赫兹生物传感器，它在0.82共振峰处展现出35的高品质因数。设计并制作了一种具有电磁诱导透明效应的结构，以实现太赫兹响应的米氏共振。该生物传感器对细胞因子白细胞介素2（IL-2）的检测限为100 pg/mL，并且在100 pg/mL至1 μg/mL范围内对IL-2浓度的对数呈线性响应。本研究表明该传感器在血清中细胞因子检测方面具有重要潜力，并且在细胞因子释放综合征的临床检测中具有潜在应用价值。