Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
J Med Virol. 2024 Jan;96(1):e29375. doi: 10.1002/jmv.29375.
Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease with a high fatality rate. Cardiac injury in SFTS patients is a major concern. This study aimed to evaluate the prevalence of cardiac injury and its association with mortality in hospitalized patients infected with novel Bunyavirus. Cardiac injury was defined as the presence of any of the following abnormalities: (1) blood levels of cardiac biomarkers (creatine kinase-MB, troponin-I, B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide); (2) new abnormalities in electrocardiography. The 203 SFTS patients were included in the final analysis. The proportion of SFTS patients developing cardiac injury during hospitalization was 71.4% (145/203). Compared with the uninjured group, the cardiac injury group had the severity of cardiac injury was underscored by higher median hospital costs (31420 vs. 12911, p < 0.001), higher proportion of intensive care units admissions (13.1% vs. 3.4%, p = 0.041), and higher hospital mortality rate (33.8% vs. 6.9%, p < 0.001). Multivariable-adjusted Cox proportional hazards regression analysis showed that cardiac injury was associated with higher mortality during hospitalization (hazards ratio, 7.349; 95% CI: 2.352-22.960). Cardiac injury is common among hospitalized SFTS patients, and it is associated with higher risk of mortality.
严重发热伴血小板减少综合征（SFTS）是一种具有高病死率的新发传染病。SFTS 患者的心脏损伤是一个主要关注点。本研究旨在评估新型布尼亚病毒感染住院患者中心脏损伤的发生率及其与病死率的关系。心脏损伤定义为存在以下任何异常：（1）心脏标志物（肌酸激酶同工酶-MB、肌钙蛋白 I、B 型利钠肽或 N 末端 B 型利钠肽）的血液水平升高；（2）心电图出现新的异常。共纳入 203 例 SFTS 患者进行最终分析。住院期间发生心脏损伤的 SFTS 患者比例为 71.4%（145/203）。与未损伤组相比，心脏损伤组的心脏损伤严重程度更高，中位住院费用更高（31420 比 12911，p<0.001），入住重症监护病房的比例更高（13.1%比 3.4%，p=0.041），住院病死率也更高（33.8%比 6.9%，p<0.001）。多变量调整的 Cox 比例风险回归分析显示，心脏损伤与住院期间更高的病死率相关（危险比，7.349；95%CI：2.352-22.960）。住院 SFTS 患者中常见心脏损伤，且与更高的病死率相关。
