Meng Tao, Ding Wenqian, Lv Dongmei, Wang Chenxu, Xu Yuanhong
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Public Health. 2024 Dec 17;12:1459712. doi: 10.3389/fpubh.2024.1459712. eCollection 2024.
Severe fever with thrombocytopenia syndrome (SFTS) is a serious infectious disease. This study explored the prognostic value of lactate dehydrogenase (LDH) to albumin (ALB) ratio (LAR) levels in fatal outcomes of the disease.
Two-hundred and nine patients with SFTS were enrolled in this study. Based on the prognosis, patients were divided into survival and deceased groups. Laboratory metrics were compared by univariate Cox regression and multivariate Cox regression analyses. The prognostic risk factors for SFTS disease were discussed, and the receiver operator characteristic (ROC) curve and the Kaplan-Meier survival curve were plotted to analyze the predictive value of independent risk factors on disease prognosis.
A total of 209 patients with SFTS, including 152 in the survival group and 57 in the death group, were enrolled. The median age of 209 SFTS patients was 64 years. Three indicators, age, aspartate aminotransferase (AST), and LAR, were identified as predictors of mortality in patients with SFTS. The area under the ROC curve of LAR was the highest (0.835), followed by that of AST (0.794), and age (0.720). The Kaplan-Meier survival curve showed an increased case fatality rate, of >1.4691, in patients with LAR.
Elevated LAR level on admission is an independent risk factor for fatal outcomes in patients with SFTS; this can help healthcare professionals identify patients with SFTS having a high risk of fatal outcomes.
发热伴血小板减少综合征（SFTS）是一种严重的传染病。本研究探讨了乳酸脱氢酶（LDH）与白蛋白（ALB）比值（LAR）水平对该疾病死亡结局的预后价值。
本研究纳入了209例SFTS患者。根据预后情况，将患者分为存活组和死亡组。通过单因素Cox回归和多因素Cox回归分析比较实验室指标。讨论了SFTS疾病的预后危险因素，并绘制受试者工作特征（ROC）曲线和Kaplan-Meier生存曲线，以分析独立危险因素对疾病预后的预测价值。
共纳入209例SFTS患者，其中存活组152例，死亡组57例。209例SFTS患者的中位年龄为64岁。年龄、天冬氨酸转氨酶（AST）和LAR这三个指标被确定为SFTS患者死亡率的预测因素。LAR的ROC曲线下面积最高（0.835），其次是AST（0.794）和年龄（0.720）。Kaplan-Meier生存曲线显示，LAR>1.4691的患者病死率增加。
入院时LAR水平升高是SFTS患者死亡结局的独立危险因素；这有助于医护人员识别具有高死亡风险的SFTS患者。
