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中国肝硬化伴腹水患者再入院的危险因素:一项回顾性观察研究。

Risk factors for hospital readmission among patients with cirrhosis and ascites in China: a retrospective observational study.

机构信息

Department of Nursing, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

出版信息

J Int Med Res. 2024 Jan;52(1):3000605231223087. doi: 10.1177/03000605231223087.

DOI:10.1177/03000605231223087
PMID:38258740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10807325/
Abstract

OBJECTIVE

In this investigation, we aimed to explore risk factors for 90-day hospital readmission among patients with cirrhosis and ascites in an Asian population.

METHODS

In this retrospective study, we included consecutive patients diagnosed with cirrhosis and ascites hospitalized in Renji Hospital between 2018 and 2022 to elucidate risk factors for 90-day readmission. We conducted multivariate logistic regression analysis to identify readmission risk factors.

RESULTS

We included 265 patients with cirrhosis and ascites. A 43% readmission rate was observed within 90 days. After adjustment for multiple covariates, we found that readmission within 90 days was independently linked to reduced levels of hemoglobin (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.94-0.97) and serum albumin (OR 0.88, 95% CI 0.83-0.93), and higher Model for End-Stage Liver Disease and sodium (MELD-Na) scores (OR 1.04, 95% CI 1.01-1.07) at discharge.

CONCLUSIONS

Patients with cirrhosis who have ascites are frequently rehospitalized within 90 days after discharge. Lower hemoglobin or albumin and higher MELD-Na scores at discharge may be the main risk factors for hospital readmission.

摘要

目的

本研究旨在探讨亚洲人群肝硬化伴腹水患者 90 天内住院再入院的危险因素。

方法

本回顾性研究纳入了 2018 年至 2022 年期间在仁济医院住院的连续诊断为肝硬化伴腹水的患者,以阐明 90 天再入院的危险因素。我们进行了多变量逻辑回归分析以确定再入院的危险因素。

结果

我们纳入了 265 例肝硬化伴腹水患者。在 90 天内,有 43%的患者再入院。在调整了多个协变量后,我们发现 90 天内再入院与血红蛋白水平降低(比值比 [OR] 0.96,95%置信区间 [CI] 0.94-0.97)和血清白蛋白水平降低(OR 0.88,95% CI 0.83-0.93)独立相关,而出院时的终末期肝病模型和钠(MELD-Na)评分较高(OR 1.04,95% CI 1.01-1.07)。

结论

肝硬化伴腹水患者出院后 90 天内再次住院的情况较为常见。出院时血红蛋白或白蛋白水平较低,MELD-Na 评分较高可能是医院再入院的主要危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3063/10807325/fd096706c3a8/10.1177_03000605231223087-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3063/10807325/fd096706c3a8/10.1177_03000605231223087-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3063/10807325/fd096706c3a8/10.1177_03000605231223087-fig1.jpg

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本文引用的文献

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Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions.肝硬化及其相关并发症的流行病学:当前知识和未来方向。
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Predictors of Three-month Hospital Readmissions and Mortality in Patients with Cirrhosis of Liver.肝硬化患者三个月内再次入院及死亡的预测因素
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Risk Factors for Liver Cirrhosis-Related Readmissions in the Largest Ethnic Minority in United States.美国最大少数族裔中肝硬化相关再入院的风险因素
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Predictive models of mortality and hospital readmission of patients with decompensated liver cirrhosis.失代偿期肝硬化患者死亡率和再入院率的预测模型。
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Predictors of 1-month and 3-months Hospital Readmissions in Decompensated Cirrhosis: A Prospective Study in a Large Asian Cohort.失代偿期肝硬化 1 个月和 3 个月再住院的预测因素:一项大型亚洲队列的前瞻性研究。
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Nationwide estimates and risk factors of hospital readmission in patients with cirrhosis in the United States.美国肝硬化患者再住院的全国估计数和危险因素。
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