Ghazizadeh Matin, Goljanian Tabrizi Ali, Rajabi Najmeh
Department of Otorhinolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Otorhinolaryngol. 2024 Jan;36(1):349-353. doi: 10.22038/IJORL.2023.75247.3524.
Since sinonasal polyposis (SNP) has a high recurrence rate after surgery, various studies have investigated the effect of corticosteroid medications to prevent disease recurrence. The present study was designed to compare the effect of three forms of local corticosteroids on preventing SNP recurrence post-operatively.
This double-blind, randomized clinical trial study was conducted on 108 patients with SNP who underwent functional endoscopic sinus surgery (FESS). Permuted Block Randomization randomly assigned patients into three groups of 36 people: budesonide spray, betamethasone drop, and budesonide nebulizing suspension groups. One and six months after surgery, the patients were evaluated for recurrence of SNP by nasal endoscopy. SNOT 22 questionnaire was used to assess patients' subjective improvement rate pre- and post-operatively.
According to the scores obtained in the Modified Lund-Kennedy Scoring, budesonide nebulizing suspension showed better effects on preventing the recurrence of sino-nasal polyps after FESS compared with betamethasone nasal drops. The score was significantly lower in the budesonide nebulizing suspension group compared to the betamethasone drop group (P=0.043). There was no statistically significant difference in the scores between the budesonide nebulizing suspension group and the betamethasone spray group (P=0.178). Also, we observed significant improvement in facial fullness in patients who received Budesonide nebulizing suspension.
Budesonide nebulizing suspension, compared to betamethasone nasal drops, showed better effects on preventing the recurrence of SNP after FESS.
由于鼻息肉病（SNP）术后复发率较高，各种研究已调查了皮质类固醇药物预防疾病复发的效果。本研究旨在比较三种局部皮质类固醇对预防SNP术后复发的效果。
本双盲、随机临床试验研究针对108例接受功能性鼻内镜鼻窦手术（FESS）的SNP患者开展。采用置换区组随机化将患者随机分为三组，每组36人：布地奈德喷雾剂组、倍他米松滴剂组和布地奈德雾化混悬液组。术后1个月和6个月，通过鼻内镜检查评估患者SNP的复发情况。采用SNOT 22问卷评估患者术前和术后的主观改善率。
根据改良Lund-Kennedy评分获得的分数，与倍他米松滴鼻剂相比，布地奈德雾化混悬液在预防FESS术后鼻息肉复发方面显示出更好的效果。布地奈德雾化混悬液组的分数显著低于倍他米松滴剂组（P=0.043）。布地奈德雾化混悬液组与倍他米松喷雾剂组的分数之间无统计学显著差异（P=0.178）。此外，我们观察到接受布地奈德雾化混悬液治疗的患者面部饱满度有显著改善。
与倍他米松滴鼻剂相比，布地奈德雾化混悬液在预防FESS术后SNP复发方面显示出更好的效果。
