ICMR - Vector Control Research Centre, Puducherry, India.
Indian Council of Medical Research, Hqrs New Delhi, India.
Front Public Health. 2024 Jan 8;11:1228217. doi: 10.3389/fpubh.2023.1228217. eCollection 2023.
is geographically the most widely dispersed human malaria parasite species. It has shown resilience and a great deal of adaptability. Genomic studies suggest that originated from Asia or Africa and moved to the rest of the world. Although is evolutionarily an older species than , its biology, transmission, pathology, and control still require better elucidation. poses problems for malaria elimination because of the ability of a single primary infection to produce multiple relapses over months and years. malaria elimination program needs early diagnosis, and prompt and complete radical treatment, which is challenging, to simultaneously exterminate the circulating parasites and dormant hypnozoites lodged in the hepatocytes of the host liver. As prompt surveillance and effective treatments are rolled out, preventing primaquine toxicity in the patients having glucose-6-phosphate dehydrogenase (G6PD) deficiency should be a priority for the elimination program. This review sheds light on the burden of , changing epidemiological patterns, the hurdles in elimination efforts, and the essential tools needed not just in India but globally. These tools encompass innovative treatments for eliminating dormant parasites, coping with evolving drug resistance, and the development of potential vaccines against the parasite.
是地理上分布最广泛的人类疟疾寄生虫物种。它表现出了很强的弹性和适应性。基因组研究表明，起源于亚洲或非洲，并传播到世界其他地区。虽然比更古老，但它的生物学、传播、病理学和控制仍需要更好地阐明。对疟疾消除构成了挑战，因为单次原发性感染能够在数月和数年内产生多次复发。疟疾消除计划需要早期诊断，并及时和彻底的根治性治疗，这是具有挑战性的，需要同时消灭循环寄生虫和潜伏在宿主肝脏肝细胞中的休眠疟原虫。随着及时的监测和有效的治疗措施的推出，预防葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症患者的伯氨喹毒性应该是消除计划的优先事项。本文综述了的负担、不断变化的流行病学模式、消除工作中的障碍以及不仅在印度而且在全球都需要的基本工具。这些工具包括消除休眠寄生虫的创新治疗方法、应对不断演变的药物耐药性以及针对寄生虫的潜在疫苗的开发。
