Kulaba Nicholas, Kayanja Adrian, Naigaga Josephine, Dumo Jackson Lodiong, Najjuma Josephine, Mukasa Mark Kaddu, Katabira Elly T, Moore Shirley M, Sajatovic Martha, Muyingo Anthony
Mbarara University of Science and Technology.
Makerere University.
Res Sq. 2024 Jan 8:rs.3.rs-3764472. doi: 10.21203/rs.3.rs-3764472/v1.
Stroke is an inflammatory state that causes death and chronic disability. Inflammation and oxidative stress are a predictor of poor clinical outcome, its effects are controversial and has not been evaluated in Sub-Saharan Africa (SSA).
We conducted a prospective cohort study of CT head confirmed ischemic and hemorrhagic stroke admitted within 7 days of onset of motor weakness. Baseline CRP, NLR and baseline glucose was measured with subsequent modified Rankin Scale (mRS) score on day 14 post-stroke. Cox proportional hazard model was fitted to determine hazard ratios of mortality with CRP, NLR and blood glucose.
Out of 120 patients, 51.7% were female, 52.5% had ischemic stroke and the overall median age was 65 (IQR 54-80) years. Nineteen (15.8%) patients died within a median survival time of 7 days, while 32 (25.8%) died by day 14 after stroke.
High C-reactive protein and stroke related hyperglycemia conferred statistically significant hazards of mortality among patients with acute and subacute stroke.
中风是一种导致死亡和慢性残疾的炎症状态。炎症和氧化应激是临床预后不良的预测指标，其影响存在争议，且尚未在撒哈拉以南非洲地区（SSA）进行评估。
我们对运动无力发作7天内入院的经CT头颅证实的缺血性和出血性中风患者进行了一项前瞻性队列研究。测量基线C反应蛋白、中性粒细胞与淋巴细胞比值（NLR）和基线血糖，并在中风后第14天进行改良Rankin量表（mRS）评分。采用Cox比例风险模型确定C反应蛋白、NLR和血糖与死亡率的风险比。
120例患者中，51.7%为女性，52.5%为缺血性中风，总体中位年龄为65岁（四分位间距54 - 80岁）。19例（15.8%）患者在中位生存时间7天内死亡，32例（25.8%）在中风后第14天死亡。
高C反应蛋白和中风相关高血糖在急性和亚急性中风患者中具有统计学意义的死亡风险。
