Wu Meijuan, Wu Shengnan, Tan Shidong, Xu Qingxin, Zhang Donghai, Sun Jiaxue, Yang Haoyu, Wang Cancan, Duan Tao, Xu Yao, Wei Zhiyun
Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Bioeng Biotechnol. 2024 Jan 8;11:1310149. doi: 10.3389/fbioe.2023.1310149. eCollection 2023.
Intrauterine adhesions (IUA), also known as Asherman's syndrome, is caused by trauma to the pregnant or non-pregnant uterus, which leads to damaged endometrial basal lining and partial or total occlusion of the uterine chambers, resulting in abnormal menstruation, infertility, or recurrent miscarriage. The essence of this syndrome is endometrial fibrosis. And there is no effective treatment for IUA to stimulate endometrial regeneration currently. Recently, menstrual blood-derived stem cells (MenSCs) have been proved to hold therapeutic promise in various diseases, such as myocardial infarction, stroke, diabetes, and liver cirrhosis. In this study, we examined the effects of MenSCs on the repair of uterine adhesions in a rat model, and more importantly, promoted such therapeutic effects via a xeno-free VitroGel MMP carrier. This combined treatment reduced the expression of inflammatory factors, increased the expression of anti-inflammatory factors, restricted the area of endometrial fibrosis, diminished uterine adhesions, and partially restored fertility, showing stronger effectiveness than each component alone and almost resembling the sham group. Our findings suggest a highly promising strategy for IUA treatment.
宫腔粘连（IUA），也称为阿谢曼综合征，是由妊娠或非妊娠子宫受到创伤引起的，这会导致子宫内膜基底层受损以及子宫腔部分或完全闭塞，从而导致月经异常、不孕或反复流产。该综合征的本质是子宫内膜纤维化。目前尚无有效治疗IUA以刺激子宫内膜再生的方法。最近，月经血源性干细胞（MenSCs）已被证明在多种疾病中具有治疗前景，如心肌梗死、中风、糖尿病和肝硬化。在本研究中，我们检测了MenSCs对大鼠模型子宫粘连修复的影响，更重要的是，通过无动物源的VitroGel MMP载体促进了这种治疗效果。这种联合治疗降低了炎症因子的表达，增加了抗炎因子的表达，限制了子宫内膜纤维化的面积，减少了子宫粘连，并部分恢复了生育能力，显示出比单独使用每种成分更强的有效性，且几乎与假手术组相似。我们的研究结果表明了一种极有前景的IUA治疗策略。
