视网膜脱离玻璃体切除术后多焦视网膜电图及光学相干断层扫描结果与视力的相关性：一项观察性研究。

Correlation between multifocal electroretinogram and optical coherence tomography findings with visual acuity after vitrectomy surgery for retinal detachment: an observational study.

作者信息

Hassan Asmaa, Abdel-Radi Mahmoud, Aly Mohamed Omar M, Alattar Sara

机构信息

Department of Ophthalmology, New Valley University, New Valley, Egypt.

Department of Ophthalmology, Assiut University, Assiut, Egypt.

出版信息

Int J Retina Vitreous. 2024 Jan 23;10(1):10. doi: 10.1186/s40942-024-00527-7.

DOI:10.1186/s40942-024-00527-7

PMID:38263142

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10804544/

Abstract

BACKGROUND

Despite the marked increase in the anatomical success rates of macula-off rhegmatogenous retinal detachment (RRD) surgery, patients may still complain about unsatisfactory visual outcome. This study aims to correlate the postoperative corrected distance visual acuity (CDVA) with the mf-ERG (multifocal electroretinogram) and OCT (optical coherence tomography) findings following vitrectomy surgery for RRD.

PATIENTS AND METHODS

This retrospective observational study included 40 eyes of 40 patients who underwent successful vitrectomy surgery for macula-off RRD. CDVA, mf-ERG amplitudes, mf-ERG latencies, the central macular thickness (CMT) and the integrity of the inner segment/outer segment (IS/OS) junction assessed by OCT, were evaluated 6 months postoperatively. The correlations between CDVA with mf-ERG amplitudes, mf-ERG latencies, central macular thickness, and IS/OS junction integrity were analyzed.

RESULTS

There was a statistically significant moderate positive correlation between CDVA of the studied eyes with mf-ERG amplitudes of N1, P1 and N2 in ring 1 (P = 0.008; P < 0.001 and P = 0.004, respectively), CMT (P < 0.001), and the integrity of IS/OS junction (P < 0.001). There was no significant correlation between CDVA and mf-ERG latencies in ring 1 (P > 0.05). Linear regression analysis revealed that CDVA was significantly associated with mf-ERG amplitudes and the IS/OS junction integrity. In addition, there was a strong positive correlation between mf-ERG amplitudes in ring 1 and the IS/OS junction integrity.

CONCLUSIONS

The integrated interpretation of postoperative CDVA, multifocal ERG parameters, and OCT findings provides useful information about functional visual recovery and retinal microstructural changes following vitrectomy for macula-off RRD surgery. The positive correlation between the IS/OS junction integrity and the mf-ERG amplitudes was stronger than the correlation between the IS/OS junction integrity and CDVA suggesting that mf-ERG may be superior to CDVA in reflecting the extent of microstructural damage in the photoreceptor layer.

TRIAL REGISTRATION

Clinicaltrials.gov, NCT05993208. Registered 15 August 2023 - Retrospectively registered, https://classic.

CLINICALTRIALS

gov/ct2/show/NCT05993208 .

摘要

背景

尽管黄斑脱离性孔源性视网膜脱离（RRD）手术的解剖成功率显著提高，但患者仍可能抱怨视觉效果不尽人意。本研究旨在将玻璃体切除术后矫正远视力（CDVA）与RRD玻璃体切除术后的多焦视网膜电图（mf-ERG）和光学相干断层扫描（OCT）结果进行关联分析。

患者与方法

本回顾性观察研究纳入了40例成功接受黄斑脱离性RRD玻璃体切除术患者的40只眼。术后6个月评估CDVA、mf-ERG振幅、mf-ERG潜伏期、中心黄斑厚度（CMT）以及通过OCT评估的内节/外节（IS/OS）连接的完整性。分析CDVA与mf-ERG振幅、mf-ERG潜伏期、中心黄斑厚度和IS/OS连接完整性之间的相关性。

结果

研究眼的CDVA与环1中N1、P1和N2的mf-ERG振幅（分别为P = 0.008；P < 0.001和P = 0.004）、CMT（P < 0.001）以及IS/OS连接的完整性（P < 0.001）之间存在统计学上显著的中度正相关。环1中CDVA与mf-ERG潜伏期之间无显著相关性（P > 0.05）。线性回归分析显示，CDVA与mf-ERG振幅和IS/OS连接完整性显著相关。此外，环1中mf-ERG振幅与IS/OS连接完整性之间存在强正相关。

结论

术后CDVA、多焦ERG参数和OCT结果的综合解读为黄斑脱离性RRD玻璃体切除术后的功能性视力恢复和视网膜微观结构变化提供了有用信息。IS/OS连接完整性与mf-ERG振幅之间的正相关性强于IS/OS连接完整性与CDVA之间的相关性，这表明mf-ERG在反映光感受器层微观结构损伤程度方面可能优于CDVA。