Shaki Zeinab, Ghaffari Farzaneh, Alijaniha Fatemeh, Kamalinejad Mohammad, Kazemnejad Anoshiravan, Daneshfard Babak, Naseri Mohsen, Heidari Mohammad Reza
Department of Nursing, Faculty of Nursing and Midwifery, Shahed University, Tehran, Iran.
Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran.
Evid Based Complement Alternat Med. 2024 Jan 12;2024:3077603. doi: 10.1155/2024/3077603. eCollection 2024.
(AG), commonly known as dill, is a plant from the Apiaceae family that has been traditionally used as a skin softener and purifying agent in Persian medicine. In a previous study conducted on male rats, dill was found to have anti-inflammatory effects. The current study aimed to examine the efficacy of topical application of oil on pruritus severity, skin dryness, sleep quality, and quality of life in patients undergoing hemodialysis.
In the current clinical trial, the participants were randomly assigned to one of these groups: topical AG preparation, sesame oil, or a control group receiving no treatment. The study was double-blind and placebo-controlled. The topical treatment was applied twice a day for one month to areas of the skin affected by pruritus. The outcome measures included the severity of skin dryness, the Pittsburgh Sleep Quality Index, Duo's Uremic Pruritus Severity Scale, and the Itchy QoL questionnaire.
This study involved 106 hemodialysis patients, and after intervention for one month, the medication group had a significantly lower mean score of sleep quality (3.24 ± 2.41) than the placebo (4.54 ± 3.11) and control (5.05 ± 3.21) groups (=0.032). The mean change in pruritus severity was significantly greater in the medication group (-17.28 ± 8.938) than the placebo (-5.91 ± 5.398) and control (-3.43 ± 3.228) groups ( < 0.001). Moreover, a significant difference was observed in the mean changes in quality of life between the medication, placebo, and control groups, with values of -14.88 ± 7.89, -5.34 ± 4.50, and -1.92 ± 2.86, respectively ( < 0.001). Furthermore, both the medication and placebo groups showed improvement in skin dryness compared to the control group having the values of -1.65 ± 0.91, -1.11 ± 0.79, and -0.38 ± 0.54, respectively ( < 0.001).
Topical preparation significantly improved the sleep quality and quality of life and reduced skin pruritus and dryness in hemodialysis patients. It could be considered as a simple therapeutic modality to control pruritus in hemodialysis patients. This trial is registered with IRCT2017022032671N1.
莳萝（AG），通常被称为小茴香，是一种伞形科植物，在波斯医学中传统上被用作皮肤软化剂和净化剂。在之前一项对雄性大鼠进行的研究中，发现莳萝具有抗炎作用。本研究旨在探讨局部应用莳萝油对血液透析患者瘙痒严重程度、皮肤干燥、睡眠质量和生活质量的疗效。
在当前的临床试验中，参与者被随机分配到以下组之一：局部应用AG制剂组、芝麻油组或不接受治疗的对照组。该研究为双盲、安慰剂对照试验。局部治疗每天应用两次，持续一个月，涂抹于瘙痒受累的皮肤区域。观察指标包括皮肤干燥严重程度、匹兹堡睡眠质量指数、杜氏尿毒症瘙痒严重程度量表和瘙痒生活质量问卷。
本研究纳入了106例血液透析患者，干预一个月后，用药组的睡眠质量平均得分（3.24±2.41）显著低于安慰剂组（4.54±3.11）和对照组（5.05±3.21）（P=0.032）。用药组瘙痒严重程度的平均变化（-17.28±8.938）显著大于安慰剂组（-5.91±5.398）和对照组（-3.43±3.228）（P<0.001）。此外，用药组、安慰剂组和对照组在生活质量平均变化方面存在显著差异，分别为-14.88±7.89、-5.34±4.50和-1.92±2.86（P<0.001）。此外，与对照组相比，用药组和安慰剂组的皮肤干燥情况均有改善，其值分别为-1.65±0.91、-1.11±0.79和-0.38±0.54（P<0.001）。
局部应用AG制剂显著改善了血液透析患者的睡眠质量和生活质量，并减轻了皮肤瘙痒和干燥。它可被视为控制血液透析患者瘙痒的一种简单治疗方式。本试验已在伊朗临床试验注册中心注册，注册号为IRCT2017022032671N1。
