肉桂和丁香精油纳米凝胶的抗炎和镇痛作用：体内研究。

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study.

机构信息

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

出版信息

BMC Complement Med Ther. 2022 May 20;22(1):143. doi: 10.1186/s12906-022-03619-9.

BACKGROUND

Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness.

METHODS

This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies.

RESULTS

The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects.

CONCLUSION

The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.

背景

肉桂（Cinnamomum zeylanicum）和丁香（Syzygium aromaticum）精油是两种具有广泛生物特性的药用重要植物衍生物质。此外，基于纳米乳液的凝胶已被广泛用于增加局部药物递送和效果。

方法

本研究旨在探索含有精油的基于纳米乳液的凝胶在动物模型中的抗炎作用（足爪肿胀试验）和抗伤害作用（热板和福尔马林试验）。首先制备粒径为 28±6nm 和 12±3nm 的肉桂和丁香精油纳米乳液。然后通过添加羧甲基纤维素（3.5%w/v）将纳米乳液凝胶化。最后，通过 ATR-FTIR 分析对纳米凝胶进行表征，并在急性和慢性镇痛实验研究中在诱导炎症或疼痛之前将其用作局部预处理。