SPON2的生物学功能及相关信号通路
The biological functions and related signaling pathways of SPON2.
作者信息
Zhang Jingrun, Liu Ge, Liu Yuchen, Yang Pei, Xie Junyuan, Wei Xiaowei
机构信息
Zhongshan Clinical College, Dalian University, Dalian, China.
Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
出版信息
Front Oncol. 2024 Jan 9;13:1323744. doi: 10.3389/fonc.2023.1323744. eCollection 2023.
Spondin-2 (SPON2), also referred to as M-spondin or DIL-1, is a member of the extracellular matrix protein family known as Mindin-F-spondin (FS). SPON2 can be used as a broad-spectrum tumor marker for more than a dozen tumors, mainly prostate cancer. Meanwhile, SPON2 is also a potential biomarker for the diagnosis of certain non-tumor diseases. Additionally, SPON2 plays a pivotal role in regulating tumor metastasis and progression. In normal tissues, SPON2 has a variety of biological functions represented by promoting growth and development and cell proliferation. This paper presents a comprehensive overview of the regulatory mechanisms, diagnostic potential as a broad-spectrum biomarker, diverse biological functions, involvement in various signaling pathways, and clinical applications of SPON2.
脊髓灰质炎病毒受体相关蛋白2（SPON2），也被称为M-脊髓灰质炎病毒受体相关蛋白或DIL-1，是细胞外基质蛋白家族Mindin-F-脊髓灰质炎病毒受体相关蛋白（FS）的成员。SPON2可作为十几种肿瘤的广谱肿瘤标志物，主要是前列腺癌。同时，SPON2也是诊断某些非肿瘤疾病的潜在生物标志物。此外，SPON2在调节肿瘤转移和进展中起关键作用。在正常组织中，SPON2具有多种生物学功能，以促进生长发育和细胞增殖为代表。本文全面综述了SPON2的调控机制、作为广谱生物标志物的诊断潜力、多样的生物学功能、参与的各种信号通路以及临床应用。
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