Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Department of Cardiology, Nanjing Medical University, Nanjing, People's Republic of China.
Clin Exp Hypertens. 2024 Dec 31;46(1):2303999. doi: 10.1080/10641963.2024.2303999. Epub 2024 Jan 24.
The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population.
Prospective data were obtained from 3150 participants aged ≥ 18 years in the China Health and Nutrition Survey from 2009 to 2015. The AIP is a logarithmically transformed ratio of triglycerides to high-density lipoprotein cholesterol in molar concentration. Cox regression analysis was used to determine the association of AIP index with new-onset hypertension.
After the six-year follow-up, 1054 (33.4%) participants developed new-onset hypertension. The participants were divided into AIP quartile groups (Q1-Q4). Compared with those in Q1, subjects in Q3-4 had nearly 1.35 times the risk of new-onset hypertension after full adjustment [Q3: hazard ratio (HR): 1.35, 95% confidence interval (CI): 1.13-1.62; Q4: HR: 1.35, 95% CI: 1.13-1.64]. The risks of new-onset hypertension were nearly 1.30 times higher in subjects in Q2-4 than in subjects in Q1 ( < .01) after the full adjustment when we excluded subjects with diabetes and/or chronic kidney diseases. There was a significant difference [HR (CI): 1.27 (1.04-1.54) vs. 0.90 (0.69-1.18)] when subjects were divided into two groups according to body mass index (BMI) level (<24 vs. ≥24 kg/m).
The present study suggested that individuals with a higher AIP index are associated with new-onset hypertension, independent of kidney function and glucose levels. The association was stronger in subjects with normal BMI, which may provide early screening of metabolomics in hypertension prevention.
血浆致动脉粥样硬化指数（AIP）是一种新型的动脉粥样硬化代谢生物标志物。然而，在中国人群中，AIP 与新发高血压之间的关系尚未阐明。
前瞻性数据来自 2009 年至 2015 年中国健康与营养调查中的 3150 名年龄≥18 岁的参与者。AIP 是用摩尔浓度对数转换的甘油三酯与高密度脂蛋白胆固醇的比值。Cox 回归分析用于确定 AIP 指数与新发高血压之间的关系。
经过六年的随访，1054 名（33.4%）参与者发生了新发高血压。将参与者分为 AIP 四分位组（Q1-Q4）。与 Q1 组相比，Q3-4 组在充分调整后新发高血压的风险几乎增加了 1.35 倍[Q3：风险比（HR）：1.35，95%置信区间（CI）：1.13-1.62；Q4：HR：1.35，95%CI：1.13-1.64]。当排除患有糖尿病和/或慢性肾脏疾病的患者后，Q2-4 组的新发高血压风险几乎是 Q1 组的 1.30 倍（ < .01）。当根据体重指数（BMI）水平（<24 与≥24 kg/m）将受试者分为两组时，差异具有统计学意义[HR（CI）：1.27（1.04-1.54）与 0.90（0.69-1.18）]。
本研究表明，较高的 AIP 指数与新发高血压相关，与肾功能和血糖水平无关。在 BMI 正常的受试者中，这种相关性更强，这可能为高血压预防中的代谢组学早期筛查提供依据。
