Duan Zhiping, Huang Yunda, Liu Xiaoling, Tang Huiyu, Jiang Guihua, Huang Wei, Du Runfen, Zhou Dan, Yang Hong
Department of Geriatrics, The Third People's Hospital of Yunnan Province, The Second Affiliated Hospital of Dali University, 292 Beijing Road, Kunming, 650011, Yunnan Province, China.
Radiotherapy Department, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, China.
Sci Rep. 2025 Jan 17;15(1):2237. doi: 10.1038/s41598-025-86398-w.
Sarcopenia is an age-related muscle senescence disease that leads to functional limitations, physical disability and premature death in older adults. Atherogenic index of plasma (AIP) is a novel indicator of atherosclerotic status based on triglycerides and high-density lipoprotein cholesterol. The aim of this study was to investigate the association between AIP and new-onset sarcopenia and its components among middle-aged and older adults in a Chinese community. This cohort study included 7,992 participants who were free of sarcopenia in 2011 in the China Health and Retirement Longitudinal Study and were followed up in 2013 and 2015. Sarcopenia was assessed using the recommendations of the Asian Working Group for Sarcopenia 2019. Longitudinal associations between AIP and sarcopenia and its components were assessed using Cox proportional risk regression modeling. The results showed that AIP was negatively associated with sarcopenia [HR and 95% CI: 0.73 (0.62-0.86)]; with muscle mass [β and 95%CI: 0.49 (0.4-0.57)], skeletal muscle mass index [β and 95%CI: 0.17 (0.15-0.2)], and grip strength [β and 95% CI: 0.17 (0.15-0.2)] being positively correlated. A lower AIP was associated with a lower muscle mass and handgrip strength and higher incidence of sarcopenia. Regular measurement of AIP in the middle-aged and older population in the community can help in the early diagnosis and intervention of sarcopenia.
肌肉减少症是一种与年龄相关的肌肉衰老疾病，可导致老年人功能受限、身体残疾和过早死亡。血浆致动脉粥样硬化指数（AIP）是一种基于甘油三酯和高密度脂蛋白胆固醇的动脉粥样硬化状态新指标。本研究旨在探讨中国社区中老年人AIP与新发肌肉减少症及其组成成分之间的关联。这项队列研究纳入了中国健康与养老追踪调查中2011年无肌肉减少症的7992名参与者，并于2013年和2015年进行随访。采用2019年亚洲肌肉减少症工作组的建议评估肌肉减少症。使用Cox比例风险回归模型评估AIP与肌肉减少症及其组成成分之间的纵向关联。结果显示，AIP与肌肉减少症呈负相关[风险比（HR）及95%置信区间（CI）：0.73（0.62 - 0.86）]；与肌肉量[β及95%CI：0.49（0.4 - 0.57）]、骨骼肌量指数[β及95%CI：0.17（0.15 - 0.2）]和握力[β及95%CI：0.17（0.15 - 0.2）]呈正相关。较低的AIP与较低的肌肉量和握力以及较高的肌肉减少症发病率相关。定期测量社区中老年人群的AIP有助于肌肉减少症的早期诊断和干预。
