Chen Xiao, Wang Lerui, Lai Weicheng, Zhou Boda
Department of Cardiology Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University Beijing China.
School of Clinical Medicine Tsinghua University Beijing China.
Aging Med (Milton). 2025 Apr 30;8(2):107-116. doi: 10.1002/agm2.70015. eCollection 2025 Apr.
Atherosclerosis is the underlying pathology of cardiovascular disease (CVD), including hypertension. Unfortunately, the association between the atherogenic index of plasma (AIP) and hypertension has not been reported in a large-scale middle-aged and elderly population. This study aimed to evaluate the association between AIP and hypertension in a representative middle-aged and elderly population in China.
The present study was a retrospective cohort study. We conducted cross-sectional and longitudinal analysis using data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018. Hypertension was identified by self-report or by taking antihypertensive medications. Participants aged below 45 years, with missing data on AIP, hypertension records, or taking lipid-lowering medication were excluded.
A total of 12,376 participants were included in the cross-sectional analysis; we found that after adjusting for covariates, each unit increment in AIP was associated with a 109.0% increased prevalence of hypertension (OR = 2.090, 95% CI: 1.776-2.459), a 41.2% increased likelihood of systolic blood pressure (SBP) above 140 mmHg (OR = 1.412, 95% CI: 1.199-1.664), and a 43.9% increased likelihood of diastolic blood pressure (DBP) above 90 mmHg (OR = 1.439, 95% CI: 1.153-1.795). A total of 5649 participants were included in the longitudinal analysis; we found that every one-unit increase in AIP was associated with a 57.7% increase in hypertension incidence (OR = 1.577, 95% CI: 1.282-1.941, < 0.001) during 7 years follow-up.
These results demonstrated a significant positive association between AIP and the prevalence and incidence of hypertension in a nationwide representative middle-aged and elderly population in China.
动脉粥样硬化是心血管疾病（CVD）的潜在病理基础，包括高血压。遗憾的是，血浆致动脉粥样硬化指数（AIP）与高血压之间的关联在大规模中老年人群中尚未见报道。本研究旨在评估中国具有代表性的中老年人群中AIP与高血压之间的关联。
本研究为回顾性队列研究。我们使用中国健康与养老追踪调查（CHARLS）2011年至2018年的数据进行横断面和纵向分析。高血压通过自我报告或服用降压药物来确定。年龄在45岁以下、AIP数据缺失、高血压记录缺失或服用降脂药物的参与者被排除。
横断面分析共纳入12376名参与者；我们发现，在调整协变量后，AIP每增加一个单位，高血压患病率增加109.0%（OR = 2.090，95%CI：1.776 - 2.459），收缩压（SBP）高于140 mmHg的可能性增加41.2%（OR = 1.412，95%CI：1.199 - 1.664），舒张压（DBP）高于90 mmHg的可能性增加43.9%（OR = 1.439，95%CI：1.153 - 1.795）。纵向分析共纳入5649名参与者；我们发现，在7年随访期间，AIP每增加一个单位，高血压发病率增加57.7%（OR = 1.577，95%CI：1.282 - 1.941，P < 0.001）。
这些结果表明，在中国全国具有代表性的中老年人群中，AIP与高血压的患病率和发病率之间存在显著正相关。
