Morrison C E, Dutton D, Howie H, Gilmour H
Anaesthesia. 1987 Jan;42(1):7-14. doi: 10.1111/j.1365-2044.1987.tb02937.x.
A randomised double-blind comparison of pethidine and meptazinol used as analgesics in labour was carried out in 1,100 consecutive women who would normally have received intramuscular pethidine. Pain assessments at 30-minute intervals were made independently by patients and midwives. Maternal and neonatal side effects were noted. The babies' requirements for resuscitation and weight changes in the first 5 days were studied. There was no difference in the analgesia provided by the two drugs; the pattern of side effects was similar, but the incidence of vomiting was greater following meptazinol administration. The babies in the two groups were similar with respect to resuscitation received, weight gains or losses and the incidence of clinical neonatal jaundice. The most striking findings were the poor quality of pain relief experienced by both groups following parenteral analgesics and the high incidence of side effects.
对1100名通常会接受肌肉注射哌替啶的连续分娩女性进行了一项随机双盲比较，比较哌替啶和美普他酚作为分娩镇痛剂的效果。患者和助产士每隔30分钟独立进行疼痛评估。记录母婴副作用。研究了婴儿复苏需求以及出生后前5天的体重变化。两种药物提供的镇痛效果没有差异；副作用模式相似，但使用美普他酚后呕吐发生率更高。两组婴儿在接受的复苏、体重增加或减轻以及临床新生儿黄疸发生率方面相似。最显著的发现是两组在接受非肠道镇痛剂后疼痛缓解质量较差以及副作用发生率较高。
