Li D F, Rees G A, Rosen M
Department of Anesthetics, University Hospital of Wales, Cardiff, U.K.
Eur J Obstet Gynecol Reprod Biol. 1988 Feb;27(2):99-104. doi: 10.1016/0028-2243(88)90002-0.
The feasibility of patient-controlled on-demand analgesia by the intramuscular route during labour was tested on 10 primigravid mothers. Pethidine 50 mg or meptazinol 75 mg was available double-blind at minimum intervals of 20 min. The mean dose demanded was 190 (SD 96.2) mg of pethidine and 285 (SD 97.8) mg of meptazinol. The dose of pethidine is similar to that demanded by the intravenous route. Pain evaluations were not significantly different, but one mother who had meptazinol opted for epidural analgesia, and 2 wished they had done so. The system could be easily managed by all the mothers and there were not technical difficulties. Self-administered intramuscular analgesia could be instituted by a midwife with a dosage scheme similar to current practice. A field trial by midwives of self-administered intramuscular analgesia with pethidine is indicated.
对10名初产妇进行了分娩期间肌肉注射自控按需镇痛可行性的测试。50毫克哌替啶或75毫克美普他酚以双盲方式提供，最小间隔时间为20分钟。哌替啶的平均需求量为190（标准差96.2）毫克，美普他酚为285（标准差97.8）毫克。哌替啶的剂量与静脉注射途径的需求量相似。疼痛评估没有显著差异，但有一名使用美普他酚的产妇选择了硬膜外镇痛，还有2名产妇希望自己当时选择硬膜外镇痛。该系统所有产妇都能轻松操作，没有技术难题。助产士可以按照与当前做法类似的给药方案实施自我肌肉注射镇痛。建议助产士对哌替啶自我肌肉注射镇痛进行现场试验。
