Department of Physics, Concordia University, Montreal H4B 1R6, Canada.
Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
J Control Release. 2024 Mar;367:283-299. doi: 10.1016/j.jconrel.2024.01.034. Epub 2024 Jan 29.
Focused ultrasound (FUS) combined with intravascularly circulating microbubbles can transiently increase the permeability of the blood-brain barrier (BBB) to enable targeted therapeutic delivery to the brain, the clinical testing of which is currently underway in both adult and pediatric patients. Aside from traditional cancer drugs, this technique is being extended to promote the delivery of immunomodulating therapeutics to the brain, including antibodies, immune cells, and cytokines. In this manner, FUS approaches are being explored as a tool to improve and amplify the effectiveness of immunotherapy for both primary and metastatic brain cancer, a particularly challenging solid tumor to treat. Here, we present an overview of the latest groundbreaking research in FUS-assisted delivery of immunomodulating agents to the brain in pre-clinical models of brain cancer, and place it within the context of the current immunotherapy approaches. We follow this up with a discussion on new developments and emerging strategies for this rapidly evolving approach.
聚焦超声（FUS）联合血管内循环微泡可以短暂增加血脑屏障（BBB）的通透性，使靶向治疗药物能够递送到大脑，目前该技术正在成人和儿科患者中进行临床试验。除了传统的癌症药物，该技术还被扩展用于促进将免疫调节治疗药物递送到大脑，包括抗体、免疫细胞和细胞因子。通过这种方式，FUS 方法被探索作为一种工具，以提高和增强原发性和转移性脑癌的免疫治疗的效果，这是一种特别具有挑战性的实体瘤。在这里，我们介绍了在脑癌的临床前模型中，FUS 辅助递送至大脑的免疫调节药物的最新突破性研究的概述，并将其置于当前免疫治疗方法的背景下。随后，我们讨论了这种快速发展的方法的新进展和新兴策略。
