Ruikang Hospital, Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, Xingning District, Nanning City, Guangxi, 53000, China.
First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning City, Guangxi, 530021, China.
Neurol Sci. 2024 Jul;45(7):3117-3124. doi: 10.1007/s10072-024-07324-y. Epub 2024 Jan 25.
Previous research suggests that peripheral immune cells may play a role in the development of Alzheimer's disease (AD). Our study aims to determine if the composition of peripheral immune cells directly contributes to the occurrence of AD.
We utilized a two-sample Mendelian randomization (MR) approach to examine the association between peripheral immune cells and AD.The primary analysis method used was the inverse variance weighted (IVW) method, and we also conducted analyses using MR Egger, weighted median, simple mode, and weighted mode methods to ensure the accuracy of the results.Heterogeneity and horizontal pleiotropy were evaluated using Cochran's Q statistics and the MR Egger intercept, respectively.
The study found a significant correlation between increased IgD + CD24- AC cells (Odds Ratio [OR] = 1.03, 95% Confidence Interval [CI] = 1.01-1.06, P = 0.0172), increased CD4 + %leukocyte (OR = 1.08, 95% CI = 1.02-1.14, P = 0.0086), and increased CD4 + CD8dim AC cells (OR = 1.06, 95% CI = 1.01-1.11, P = 0.0218), with an increased susceptibility to AD. Conversely, an increase in EM DN (CD4-CD8-) %T cells (OR = 0.95, 95% CI = 0.92-0.99, P = 0.0164) and an increase in DN (CD4-CD8-) AC cells (OR = 0.93, 95% CI = 0.88-0.99, P = 0.0145) were associated with a protective effect against AD.
Our findings establish a causal link between peripheral immune cells and AD. This study is the first to examine the relationship between peripheral immune cells and AD using MR, offering valuable insights for early diagnosis and treatment decisions.
先前的研究表明，外周免疫细胞可能在阿尔茨海默病（AD）的发展中起作用。我们的研究旨在确定外周免疫细胞的组成是否直接导致 AD 的发生。
我们使用两样本孟德尔随机化（MR）方法来研究外周免疫细胞与 AD 之间的关联。主要分析方法是逆方差加权（IVW）法，我们还使用 MR Egger、加权中位数、简单模式和加权模式方法进行分析，以确保结果的准确性。异质性和水平遗传异质性分别用 Cochran's Q 统计量和 MR Egger 截距进行评估。
研究发现，IgD+CD24-AC 细胞（优势比 [OR] = 1.03，95%置信区间 [CI] = 1.01-1.06，P = 0.0172）、CD4+%白细胞（OR = 1.08，95%CI = 1.02-1.14，P = 0.0086）和 CD4+CD8dim AC 细胞（OR = 1.06，95%CI = 1.01-1.11，P = 0.0218）的增加与 AD 的易感性增加相关。相反，EM DN（CD4-CD8-）%T 细胞（OR = 0.95，95%CI = 0.92-0.99，P = 0.0164）和 DN（CD4-CD8-）AC 细胞（OR = 0.93，95%CI = 0.88-0.99，P = 0.0145）的增加与 AD 具有保护作用。
我们的研究结果确立了外周免疫细胞与 AD 之间的因果关系。这项研究首次使用 MR 检查外周免疫细胞与 AD 之间的关系，为早期诊断和治疗决策提供了有价值的见解。
