[急性麦普替林中毒时的心脏传导障碍]

[Heart conduction disorders in acute maprotiline poisoning].

作者信息

Colpart E, Manoury B, Daumal M, Boutillier C

出版信息

Ann Fr Anesth Reanim. 1986;5(6):623-4. doi: 10.1016/s0750-7658(86)80077-6.

Abstract

A case is reported of self-poisoning with maprotiline followed by prolonged disorders of intraventricular conduction. The cardiotoxicity of tetracyclic antidepressants was well established, but few cases were reported. Maprotiline pharmacokinetics explained the duration of the cardiovascular side-effects. The severity of maprotiline overdoses should not be underestimated.

摘要

报告了一例服用马普替林自毒事件，随后出现了长时间的室内传导障碍。四环类抗抑郁药的心脏毒性已得到充分证实，但报告的病例很少。马普替林的药代动力学解释了心血管副作用的持续时间。马普替林过量的严重性不应被低估。