致命性麦普替林中毒。

Fatal maprotiline intoxication.

作者信息

Curtis R A, Giacona N, Burrows D, Bauman J L, Schaffer M

出版信息

Drug Intell Clin Pharm. 1984 Sep;18(9):716-20. doi: 10.1177/106002808401800908.

Abstract

We report a fatal case of drug toxicity associated with torsade de pointes following an overdose of the tetracyclic antidepressant, maprotiline (Ludiomil). Tissue and plasma levels were obtained at autopsy and are noted. In addition, the cardiovascular effects, pharmacokinetics, and toxicity of maprotiline are reviewed and compared with that of tricyclic antidepressants.

摘要

我们报告了一例因过量服用四环类抗抑郁药马普替林（路滴美）导致药物毒性并伴有尖端扭转型室速的致死病例。尸检时获取了组织和血浆水平并做了记录。此外，对马普替林的心血管效应、药代动力学及毒性进行了综述，并与三环类抗抑郁药进行了比较。