K V Binoy M, Alagesan Jagatheesan
Physiotherapy, Saveetha College of Physiotherapy, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.
Cureus. 2023 Dec 25;15(12):e51072. doi: 10.7759/cureus.51072. eCollection 2023 Dec.
The immune system, the defense mechanism of the body, mainly consists of lymphocytes. The three primary subtypes of lymphocytes are natural killer cells (NK cells), bone marrow-derived lymphocytes (B-lymphocytes), and thymus-derived lymphocytes (T-lymphocytes). T-lymphocytes are mostly composed of CD (cluster of differentiation) cells, such as CD4+ and CD8+ subsets of CD cells. Immunosenescence is the term for the steady decline of the immune system with aging. There are alterations in the composition of various types of lymphocytes, especially in CD4 and CD8 T cells. The elderly are more vulnerable to infections due to immunosenescence, which raises morbidity and mortality rates. Physical exercises are believed to have the potential to alter immunosenescence and produce positive changes in immune cell composition. The extent of exercise-induced immune function changes was different in research studies owing to the differences in protocols, methodologies, testing procedures, ages, and gender compositions. The impact of an eight-week balance-based exercise intervention on immune biomarkers is investigated in this case series. In this case series, two elderly women residing in an institutional setting were exposed to an eight-week-long balanced-based supervised exercise intervention. The immunological biomarkers CD45, CD3, CD4, and CD8 were the outcome variables that were assessed. Data on the outcome variables was gathered both before and after the intervention. Using flow cytometry and single-platform technology, immune biomarkers were analyzed. Following the intervention, there was a rise in the CD45, CD3, CD4, and CD8 cell counts relative to the baseline data. The biomarkers showed only slight and statistically non-significant improvements.
免疫系统作为身体的防御机制，主要由淋巴细胞组成。淋巴细胞的三种主要亚型是自然杀伤细胞（NK细胞）、骨髓来源的淋巴细胞（B淋巴细胞）和胸腺来源的淋巴细胞（T淋巴细胞）。T淋巴细胞大多由CD（分化簇）细胞组成，例如CD细胞的CD4 +和CD8 +亚群。免疫衰老指的是免疫系统随着年龄增长而持续衰退的现象。各类淋巴细胞的组成会发生变化，尤其是CD4和CD8 T细胞。由于免疫衰老，老年人更容易受到感染，这会提高发病率和死亡率。体育锻炼被认为有可能改变免疫衰老，并使免疫细胞组成产生积极变化。由于方案、方法、测试程序、年龄和性别构成的差异，不同研究中运动引起的免疫功能变化程度有所不同。本病例系列研究了为期八周的基于平衡的运动干预对免疫生物标志物的影响。在本病例系列中，两名居住在养老院的老年女性接受了为期八周的基于平衡的有监督运动干预。免疫生物标志物CD45、CD3、CD4和CD8是评估的结果变量。在干预前后收集了结果变量的数据。使用流式细胞术和单平台技术对免疫生物标志物进行了分析。干预后，相对于基线数据，CD45、CD3、CD4和CD8细胞计数有所增加。这些生物标志物仅显示出轻微的、统计学上无显著意义的改善。
