A Case Series Tries to Answer Whether Exercise Positively Influences Immunosenescence.

The immune system, the defense mechanism of the body, mainly consists of lymphocytes. The three primary subtypes of lymphocytes are natural killer cells (NK cells), bone marrow-derived lymphocytes (B-lymphocytes), and thymus-derived lymphocytes (T-lymphocytes). T-lymphocytes are mostly composed of CD (cluster of differentiation) cells, such as CD4+ and CD8+ subsets of CD cells. Immunosenescence is the term for the steady decline of the immune system with aging. There are alterations in the composition of various types of lymphocytes, especially in CD4 and CD8 T cells. The elderly are more vulnerable to infections due to immunosenescence, which raises morbidity and mortality rates. Physical exercises are believed to have the potential to alter immunosenescence and produce positive changes in immune cell composition. The extent of exercise-induced immune function changes was different in research studies owing to the differences in protocols, methodologies, testing procedures, ages, and gender compositions. The impact of an eight-week balance-based exercise intervention on immune biomarkers is investigated in this case series. In this case series, two elderly women residing in an institutional setting were exposed to an eight-week-long balanced-based supervised exercise intervention. The immunological biomarkers CD45, CD3, CD4, and CD8 were the outcome variables that were assessed. Data on the outcome variables was gathered both before and after the intervention. Using flow cytometry and single-platform technology, immune biomarkers were analyzed. Following the intervention, there was a rise in the CD45, CD3, CD4, and CD8 cell counts relative to the baseline data. The biomarkers showed only slight and statistically non-significant improvements.