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西地那非对健康人在高原低氧环境下静息及运动状态时的疗效：一项荟萃分析。

Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis.

作者信息

Dang Zhan-Cui, Yang Zhiquan, Liu Shou, Du Guo-Mei, Jin Linde, Zhao Zhong-Zhi

机构信息

Department of Public Health, Medical College, Qinghai University, Xining, Qinghai 810000, P.R. China.

Department of Rehabilitation, Women and Children's Hospital of Qinghai Province, Xining, Qinghai 810000, P.R. China.

出版信息

Exp Ther Med. 2024 Jan 8;27(2):88. doi: 10.3892/etm.2024.12376. eCollection 2024 Feb.

DOI:10.3892/etm.2024.12376
PMID:38274336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10809317/
Abstract

The current meta-analysis aimed to fully evaluate the efficacy of Sildenafil in healthy humans at different altitudes, focusing on echocardiographic and hemodynamic parameters. Relevant studies were retrieved from the Cochrane, Embase and PubMed databases. Odds ratios (OR) were determined for dichotomous data and weighted mean differences with 95% confidence intervals (CIs) for continuous data. A total of 16 RCTs were included in the current meta-analysis. Short-term treatment with Sildenafil significantly elevated resting heart rate (P0.01) at altitudes <4,000 meters. No significant differences in heart rate were observed between the Sildenafil and placebo groups at rest and during exercise at an altitude of >4,000 meters (P0.05). Sildenafil improved resting cardiac output at an altitude of >5,000 meters (P0.01) and exercising arterial oxygen saturation at <4,000 meters (P0.01). Sildenafil reduced resting pulmonary artery systolic pressure (PASP) at altitudes >4,000 meters (P0.01) and exercising PASP at altitudes >5,000 meters (P0.01). Therefore, Sildenafil efficacy in healthy humans with high-altitude hypoxia is related to altitude and rest or exercise.

摘要

当前的荟萃分析旨在全面评估西地那非在不同海拔高度的健康人群中的疗效，重点关注超声心动图和血流动力学参数。从Cochrane、Embase和PubMed数据库中检索相关研究。对于二分数据确定比值比（OR），对于连续数据确定加权平均差及95%置信区间（CI）。本荟萃分析共纳入16项随机对照试验（RCT）。在海拔<4000米处，西地那非短期治疗显著提高静息心率（P<0.01）。在海拔>4000米处，西地那非组与安慰剂组在静息和运动时的心率无显著差异（P>0.05）。西地那非在海拔>5000米处改善静息心输出量（P<0.01），在海拔<4000米处改善运动时的动脉血氧饱和度（P<0.01）。西地那非在海拔>4000米处降低静息肺动脉收缩压（PASP）（P<0.01），在海拔>5000米处降低运动时的PASP（P<0.01）。因此，西地那非在高原低氧健康人群中的疗效与海拔高度以及静息或运动状态有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/ca489da37eb4/etm-27-02-12376-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/852aba64a95d/etm-27-02-12376-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/ff5921f92b27/etm-27-02-12376-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/3f3927439c4b/etm-27-02-12376-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/8df2fdb811ca/etm-27-02-12376-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/a012979818ee/etm-27-02-12376-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/d41f51594558/etm-27-02-12376-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/cb408aa2a87f/etm-27-02-12376-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/ad56d0472ce5/etm-27-02-12376-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/ca489da37eb4/etm-27-02-12376-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/852aba64a95d/etm-27-02-12376-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/ff5921f92b27/etm-27-02-12376-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/3f3927439c4b/etm-27-02-12376-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/8df2fdb811ca/etm-27-02-12376-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/a012979818ee/etm-27-02-12376-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/d41f51594558/etm-27-02-12376-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/cb408aa2a87f/etm-27-02-12376-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/ad56d0472ce5/etm-27-02-12376-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aad9/10809317/ca489da37eb4/etm-27-02-12376-g08.jpg

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